9C97
 
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9CMR
 | | Saccharomyces cerevisiae Tom1 HECT domain | | 分子名称: | E3 ubiquitin-protein ligase TOM1, SULFATE ION | | 著者 | Schubert, H.L, Hill, C.P. | | 登録日 | 2024-07-15 | | 公開日 | 2025-05-28 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Tom1p ubiquitin ligase structure, interaction with Spt6p, and function in maintaining normal transcript levels and the stability of chromatin in promoters.
To Be Published
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9E3B
 | | Cryo-EM structure of PRMT5/WDR77 in complex with 6S complex | | 分子名称: | Methylosome protein WDR77, Methylosome subunit pICln, Protein arginine N-methyltransferase 5, ... | | 著者 | Jin, C.Y, Hunkeler, M, Fischer, E.S. | | 登録日 | 2024-10-23 | | 公開日 | 2025-02-19 | | 実験手法 | ELECTRON MICROSCOPY (3.06 Å) | | 主引用文献 | Substrate adaptors are flexible tethering modules that enhance substrate methylation by the arginine methyltransferase PRMT5.
J.Biol.Chem., 301, 2025
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9DGZ
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9DH0
 | | The Cryo-EM structure of recombinantly expressed hUGDH in complex with UDP-4-keto-xylose | | 分子名称: | (2R,3R,4R)-3,4-dihydroxy-5-oxooxan-2-yl [(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen diphosphate (non-preferred name), UDP-glucose 6-dehydrogenase | | 著者 | Kadirvelraj, R, Walsh Jr, R.M, Wood, Z.W. | | 登録日 | 2024-09-03 | | 公開日 | 2025-03-05 | | 最終更新日 | 2025-03-12 | | 実験手法 | ELECTRON MICROSCOPY (2.38 Å) | | 主引用文献 | Cryo-EM Structure of Recombinantly Expressed hUGDH Unveils a Hidden, Alternative Allosteric Inhibitor.
Biochemistry, 64, 2025
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9EGW
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9EGV
 | | HOIL-1 RING2 domain bound to ubiquitin | | 分子名称: | CHLORIDE ION, Polyubiquitin-C, RanBP-type and C3HC4-type zinc finger-containing protein 1, ... | | 著者 | Wang, X.S, Lechtenberg, B.C. | | 登録日 | 2024-11-21 | | 公開日 | 2024-12-11 | | 最終更新日 | 2025-04-16 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | The RBR E3 ubiquitin ligase HOIL-1 can ubiquitinate diverse non-protein substrates in vitro.
Life Sci Alliance, 8, 2025
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9EC2
 | | Crystal structure of SAMHD1 dimer bound to an inhibitor obtained from high-throughput chemical tethering to the guanine antiviral acyclovir | | 分子名称: | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, FE (III) ION, N-[5-({2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methoxy]ethyl}amino)-5-oxopentyl]-4,7-dibromo-3-hydroxynaphthalene-2-carboxamide | | 著者 | Egleston, M, Dong, L, Howlader, A.H, Bhat, S, Orris, B, Lopez-Rovira, L.M, Bianchet, M.A, Greenberg, M.M, Stivers, J.T. | | 登録日 | 2024-11-13 | | 公開日 | 2025-03-12 | | 最終更新日 | 2025-03-19 | | 実験手法 | X-RAY DIFFRACTION (2.72 Å) | | 主引用文献 | Inhibitors of SAMHD1 Obtained from Chemical Tethering to the Guanine Antiviral Acyclovir.
Biochemistry, 64, 2025
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9DYB
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9DYA
 | | CHIP-TPR in complex with the Hsp70 tail | | 分子名称: | E3 ubiquitin-protein ligase CHIP, Heat shock 70 kDa protein 1A, SULFATE ION | | 著者 | Zhang, H, Nix, J.C, Page, R.C. | | 登録日 | 2024-10-13 | | 公開日 | 2025-03-26 | | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | | 主引用文献 | Phosphorylation-State Modulated Binding of HSP70: Structural Insights and Compensatory Protein Engineering.
Biorxiv, 2025
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9DJT
 | | Ternary complex structure of Cereblon-DDB1 bound to WIZ(ZF7) and the molecular glue WIZ-5 | | 分子名称: | (3S)-3-(5-{[(4R)-6-ethyl-6-azaspiro[2.5]octan-4-yl]oxy}-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione, DNA damage-binding protein 1, Protein Wiz, ... | | 著者 | Partridge, J.R, Ma, X, Ornelas, E. | | 登録日 | 2024-09-06 | | 公開日 | 2024-11-27 | | 最終更新日 | 2024-12-11 | | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | | 主引用文献 | Discovery and Optimization of First-in-Class Molecular Glue Degraders of the WIZ Transcription Factor for Fetal Hemoglobin Induction to Treat Sickle Cell Disease.
J.Med.Chem., 67, 2024
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9E6S
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9E6T
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9C12
 | | Leukotriene C4-bound Multidrug Resistance-associated Protein 2 (MRP2) | | 分子名称: | (5~{S},6~{R},7~{E},9~{E},11~{Z},14~{Z})-6-[(2~{R})-2-[[(4~{S})-4-azanyl-5-oxidanyl-5-oxidanylidene-pentanoyl]amino]-3-( 2-hydroxy-2-oxoethylamino)-3-oxidanylidene-propyl]sulfanyl-5-oxidanyl-icosa-7,9,11,14-tetraenoic acid, ATP-binding cassette sub-family C member 2, CHOLESTEROL, ... | | 著者 | Koide, E, Chen, J. | | 登録日 | 2024-05-28 | | 公開日 | 2024-12-18 | | 最終更新日 | 2025-02-12 | | 実験手法 | ELECTRON MICROSCOPY (2.75 Å) | | 主引用文献 | Structural basis for the transport and regulation mechanism of the multidrug resistance-associated protein 2.
Nat Commun, 16, 2025
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9B9P
 | | Crystal structure of Staphylococcus aureus ketol-acid reductoisomerase in complex with Mg2+, and JK-5-114 | | 分子名称: | 6-hydroxy-2-phenyl[1,3]thiazolo[4,5-d]pyrimidine-5,7(4H,6H)-dione, Ketol-acid reductoisomerase (NADP(+)), MAGNESIUM ION | | 著者 | Kurz, J.L, Lin, X, Guddat, L.W. | | 登録日 | 2024-04-03 | | 公開日 | 2025-04-09 | | 最終更新日 | 2025-07-09 | | 実験手法 | X-RAY DIFFRACTION (3.18 Å) | | 主引用文献 | A Ketol-Acid Reductoisomerase Inhibitor That Has Antituberculosis and Herbicidal Activity.
Chemistry, 31, 2025
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9D7I
 | | Cryo-EM structure of BG505 DS-SOSIP.664 with 2 CH103 KN Fabs bound | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CH103 Fab light chain, ... | | 著者 | Parsons, R.J, Acharya, P. | | 登録日 | 2024-08-16 | | 公開日 | 2025-06-04 | | 実験手法 | ELECTRON MICROSCOPY (3.68 Å) | | 主引用文献 | Acquisition of quaternary trimer interaction as a key step in the lineage maturation of a broad and potent HIV-1 neutralizing antibody.
Structure, 2025
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9D7H
 | | Cryo-EM structure of BG505 DS-SOSIP.664 with 1 CH103 KN Fab bound | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CH103 Fab light chain, ... | | 著者 | Parsons, R.J, Acharya, P. | | 登録日 | 2024-08-16 | | 公開日 | 2025-06-04 | | 実験手法 | ELECTRON MICROSCOPY (3.59 Å) | | 主引用文献 | Acquisition of quaternary trimer interaction as a key step in the lineage maturation of a broad and potent HIV-1 neutralizing antibody.
Structure, 2025
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9D7G
 | | BG505 DS-SOSIP.664 apo structure from the CH103 KN cryo-EM dataset | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Surface protein gp120, ... | | 著者 | Parsons, R.J, Acharya, P. | | 登録日 | 2024-08-16 | | 公開日 | 2025-06-04 | | 実験手法 | ELECTRON MICROSCOPY (3.58 Å) | | 主引用文献 | Acquisition of quaternary trimer interaction as a key step in the lineage maturation of a broad and potent HIV-1 neutralizing antibody.
Structure, 2025
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9D7O
 | | Cryo-EM structure of BG505 DS-SOSIP.664 with 1 CH103 Fab bound | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CH103 Fab heavy chain, ... | | 著者 | Parsons, R.J, Acharya, P. | | 登録日 | 2024-08-16 | | 公開日 | 2025-06-04 | | 実験手法 | ELECTRON MICROSCOPY (3.56 Å) | | 主引用文献 | Acquisition of quaternary trimer interaction as a key step in the lineage maturation of a broad and potent HIV-1 neutralizing antibody.
Structure, 2025
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9D7P
 | | Cryo-EM structure of BG505 DS-SOSIP.664 with 2 CH103 Fabs bound | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CH103 Fab heavy chain, ... | | 著者 | Parsons, R.J, Acharya, P. | | 登録日 | 2024-08-16 | | 公開日 | 2025-06-04 | | 実験手法 | ELECTRON MICROSCOPY (3.37 Å) | | 主引用文献 | Acquisition of quaternary trimer interaction as a key step in the lineage maturation of a broad and potent HIV-1 neutralizing antibody.
Structure, 2025
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9C6M
 | | Yasminevirus c12orf29, a 5' to 3' RNA ligase, K73M mutant | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, RNA ligase1 | | 著者 | Hu, Y, Lopez, V.A, Tagliabracci, V.S, Tomchick, D.R. | | 登録日 | 2024-06-07 | | 公開日 | 2024-10-02 | | 最終更新日 | 2025-03-05 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Biochemical and structural insights into a 5' to 3' RNA ligase reveal a potential role in tRNA ligation.
Proc.Natl.Acad.Sci.USA, 121, 2024
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9CE6
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9C6L
 | | Yasminevirus c12orf29, a 5' to 3' RNA ligase | | 分子名称: | ADENOSINE MONOPHOSPHATE, MAGNESIUM ION, RNA ligase1, ... | | 著者 | Hu, Y, Lopez, V.A, Tagliabracci, V.S, Tomchick, D.R. | | 登録日 | 2024-06-07 | | 公開日 | 2024-10-02 | | 最終更新日 | 2025-03-05 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Biochemical and structural insights into a 5' to 3' RNA ligase reveal a potential role in tRNA ligation.
Proc.Natl.Acad.Sci.USA, 121, 2024
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9EUU
 | | Structure of recombinant alpha-synuclein fibrils 1B capable of seeding GCIs in vivo | | 分子名称: | Alpha-synuclein | | 著者 | Burger, D, Kashyrina, M, Lewis, A, De Nuccio, F, Mohammed, I, de La Seigliere, H, van den Heuvel, L, Feuillie, C, Verchere, J, Berbon, M, Arotcarena, M, Retailleau, A, Bezard, E, Laferriere, F, Loquet, A, Bousset, L, Baron, T, Lofrumento, D.D, De Giorgi, F, Stahlberg, H, Ichas, F. | | 登録日 | 2024-03-28 | | 公開日 | 2024-06-05 | | 最終更新日 | 2025-06-18 | | 実験手法 | ELECTRON MICROSCOPY (1.93 Å) | | 主引用文献 | 1.94 angstrom structure of synthetic alpha-synuclein fibrils seeding MSA neuropathology
Biorxiv, 2024
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9DIK
 | | Crystal structure of Plasmodium falciparum dihydroorotate dehydrogenase bound with Inhibitor DSM681 (N-cyclopropyl-1,4-dimethyl-5-((6-(trifluoromethyl)pyridin-3-yl)methyl)-1H-pyrazole-3-carboxamide) | | 分子名称: | 6-[bis(oxidanyl)methyl]-5~{H}-pyrimidine-2,4-dione, Dihydroorotate dehydrogenase (quinone), mitochondrial, ... | | 著者 | Deng, X, Tomchick, D, Phillips, M. | | 登録日 | 2024-09-05 | | 公開日 | 2025-01-01 | | 最終更新日 | 2025-01-29 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structure-Based Discovery and Development of Highly Potent Dihydroorotate Dehydrogenase Inhibitors for Malaria Chemoprevention.
J.Med.Chem., 68, 2025
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