1PV0
 
 | | Structure of the Sda antikinase | | 分子名称: | Sda | | 著者 | Rowland, S.L, Burkholder, W.F, Maciejewski, M.W, Grossman, A.D, King, G.F. | | 登録日 | 2003-06-26 | | 公開日 | 2004-04-13 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure and mechanism of Sda: an inhibitor of the histidine kinases that regulate initiation of sporulation in Bacillus subtilis
Mol.Cell, 13, 2004
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6TFL
 | | Lsm protein (SmAP) from Halobacterium salinarum | | 分子名称: | CALCIUM ION, GLYCEROL, RNA-binding protein Lsm, ... | | 著者 | Nikulin, A.D, Fando, M.S, Lekontseva, N.V. | | 登録日 | 2019-11-14 | | 公開日 | 2020-11-25 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.397 Å) | | 主引用文献 | Structure and RNA-Binding Properties of Lsm Protein from Halobacterium salinarum.
Biochemistry Mosc., 86, 2021
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6TIW
 | | Human kinesin-5 motor domain in the GSK state bound to microtubules (Conformation 2) | | 分子名称: | 6-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1~{H}-quinolin-2-one, Kinesin-like protein KIF11, MAGNESIUM ION, ... | | 著者 | Pena, A, Sweeney, A, Cook, A.D, Moores, C.A, Topf, M. | | 登録日 | 2019-11-22 | | 公開日 | 2020-03-04 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Structure of Microtubule-Trapped Human Kinesin-5 and Its Mechanism of Inhibition Revealed Using Cryoelectron Microscopy.
Structure, 28, 2020
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2XVA
 | | Crystal structure of the tellurite detoxification protein TehB from E. coli in complex with sinefungin | | 分子名称: | SINEFUNGIN, TELLURITE RESISTANCE PROTEIN TEHB, ZINC ION | | 著者 | Choudhury, H.G, Cameron, A.D, Iwata, S, Beis, K. | | 登録日 | 2010-10-25 | | 公開日 | 2011-02-16 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structure and Mechanism of the Chalcogen Detoxifying Protein Tehb from Escherichia Coli.
Biochem.J., 435, 2011
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6TA4
 | | Human kinesin-5 motor domain in the AMPPNP state bound to microtubules | | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein KIF11, MAGNESIUM ION, ... | | 著者 | Pena, A.P, Sweeney, A, Cook, A.D, Moores, C.A, Topf, M. | | 登録日 | 2019-10-29 | | 公開日 | 2020-03-04 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (6.1 Å) | | 主引用文献 | Structure of Microtubule-Trapped Human Kinesin-5 and Its Mechanism of Inhibition Revealed Using Cryoelectron Microscopy.
Structure, 28, 2020
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6T8S
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6TA3
 | | Human kinesin-5 motor domain in the GSK-1 state bound to microtubules (Conformation 1) | | 分子名称: | 6-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1~{H}-quinolin-2-one, Kinesin-like protein KIF11, MAGNESIUM ION, ... | | 著者 | Pena, A, Sweeney, A, Cook, A.D, Moores, C.A, Topf, M. | | 登録日 | 2019-10-29 | | 公開日 | 2020-04-22 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Structure of Microtubule-Trapped Human Kinesin-5 and Its Mechanism of Inhibition Revealed Using Cryoelectron Microscopy.
Structure, 28, 2020
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2XUT
 | | Crystal structure of a proton dependent oligopeptide (POT) family transporter. | | 分子名称: | PROTON/PEPTIDE SYMPORTER FAMILY PROTEIN | | 著者 | Newstead, S, Drew, D, Cameron, A.D, Postis, V.L, Xia, X, Fowler, P.W, Ingram, J.C, Carpenter, E.P, Sansom, M.S.P, McPherson, M.J, Baldwin, S.A, Iwata, S. | | 登録日 | 2010-10-21 | | 公開日 | 2010-12-15 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (3.62 Å) | | 主引用文献 | Crystal Structure of a Prokaryotic Homologue of the Mammalian Oligopeptide-Proton Symporters, Pept1 and Pept2.
Embo J., 30, 2011
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2YJA
 | | Stapled Peptides binding to Estrogen Receptor alpha. | | 分子名称: | ESTRADIOL, ESTROGEN RECEPTOR, STAPLED PEPTIDE | | 著者 | Phillips, C, Roberts, L.R, Schade, M, Bazin, R, Bent, A, Davies, N.L, Irving, S.L, Moore, R, Pannifer, A.D, Brown, D.G, Pickford, A.R, Scott, A, Xu, B. | | 登録日 | 2011-05-19 | | 公開日 | 2011-08-03 | | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | | 主引用文献 | Design and Structure of Stapled Peptides Binding to Estrogen Receptors.
J.Am.Chem.Soc., 133, 2011
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1QIP
 | | HUMAN GLYOXALASE I COMPLEXED WITH S-P-NITROBENZYLOXYCARBONYLGLUTATHIONE | | 分子名称: | BETA-MERCAPTOETHANOL, PROTEIN (LACTOYLGLUTATHIONE LYASE), S-P-NITROBENZYLOXYCARBONYLGLUTATHIONE, ... | | 著者 | Cameron, A.D, Ridderstrom, M, Olin, B, Mannervik, B. | | 登録日 | 1999-06-14 | | 公開日 | 1999-11-24 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | | 主引用文献 | Reaction mechanism of glyoxalase I explored by an X-ray crystallographic analysis of the human enzyme in complex with a transition state analogue.
Biochemistry, 38, 1999
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5F8A
 | | Crystal structure of the ternary EcoRV-DNA-Lu complex with uncleaved DNA substrate. Lanthanide binding to EcoRV-DNA complex inhibits cleavage. | | 分子名称: | 1,2-ETHANEDIOL, DNA (5'-D(*AP*AP*AP*GP*AP*TP*AP*TP*CP*TP*TP*T)-3'), LUTETIUM (III) ION, ... | | 著者 | Sangani, S.S, Kehr, A.D, Sinha, K, Rule, G.S, Jen-Jacobson, L. | | 登録日 | 2015-12-09 | | 公開日 | 2016-11-09 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | | 主引用文献 | Metal Ion Binding at the Catalytic Site Induces Widely Distributed Changes in a Sequence Specific Protein-DNA Complex.
Biochemistry, 55, 2016
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2YYY
 | | Crystal structure of Glyceraldehyde-3-phosphate dehydrogenase | | 分子名称: | Glyceraldehyde-3-phosphate dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | 著者 | Malay, A.D, Bessho, Y, Padmanabhan, B, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | 登録日 | 2007-05-02 | | 公開日 | 2007-11-06 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Structure of glyceraldehyde-3-phosphate dehydrogenase from the archaeal hyperthermophile Methanocaldococcus jannaschii.
Acta Crystallogr.,Sect.F, 65, 2009
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2YA1
 | | Product complex of a multi-modular glycogen-degrading pneumococcal virulence factor SpuA | | 分子名称: | PUTATIVE ALKALINE AMYLOPULLULANASE, SODIUM ION, SULFATE ION, ... | | 著者 | Lammerts van Bueren, A, Ficko-Blean, E, Pluvinage, B, Hehemann, J.H, Higgins, M.A, Deng, L, Ogunniyi, A.D, Stroeher, U.H, Warry, N.E, Burke, R.D, Czjzek, M, Paton, J.C, Vocadlo, D.J, Boraston, A.B. | | 登録日 | 2011-02-17 | | 公開日 | 2011-04-20 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | The Conformation and Function of a Multimodular Glycogen-Degrading Pneumococcal Virulence Factor.
Structure, 19, 2011
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2YEW
 | | Modeling Barmah Forest virus structural proteins | | 分子名称: | CAPSID PROTEIN, E1 ENVELOPE GLYCOPROTEIN, E2 ENVELOPE GLYCOPROTEIN | | 著者 | Kostyuchenko, V.A, Jakana, J, Liu, X, Haddow, A.D, Aung, M, Weaver, S.C, Chiu, W, Lok, S.M. | | 登録日 | 2011-03-31 | | 公開日 | 2012-04-18 | | 最終更新日 | 2019-10-23 | | 実験手法 | ELECTRON MICROSCOPY (5 Å) | | 主引用文献 | The Structure of Barmah Forest Virus as Revealed by Cryo-Electron Microscopy at a 6-Angstrom Resolution Has Detailed Transmembrane Protein Architecture and Interactions.
J.Virol., 85, 2011
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6U76
 | | Structure of methanesulfinate monooxygenase MsuC from Pseudomonas fluorescens. | | 分子名称: | methanesulfinate monooxygenase | | 著者 | Soule, J, Gnann, A.D, Parker, M.J, McKenna, K.C, Nguyen, S.V, Phan, N.T, Wicht, D.K, Dowling, D.P. | | 登録日 | 2019-08-31 | | 公開日 | 2020-11-11 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | To be published
To Be Published
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2YA0
 | | Catalytic Module of the Multi-modular glycogen-degrading pneumococcal virulence factor SpuA | | 分子名称: | CALCIUM ION, GLYCEROL, PUTATIVE ALKALINE AMYLOPULLULANASE, ... | | 著者 | Lammerts van Bueren, A, Ficko-Blean, E, Pluvinage, B, Hehemann, J.H, Higgins, M.A, Deng, L, Ogunniyi, A.D, Stroeher, U.H, Warry, N.E, Burke, R.D, Czjzek, M, Paton, J.C, Vocadlo, D.J, Boraston, A.B. | | 登録日 | 2011-02-17 | | 公開日 | 2011-04-20 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | The Conformation and Function of a Multimodular Glycogen-Degrading Pneumococcal Virulence Factor.
Structure, 19, 2011
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6UMX
 | | Structural basis for specific inhibition of extracellular activation of pro/latent myostatin by SRK-015 | | 分子名称: | GL29H4-16 Fab Heavy Chain,GL29H4-16 Fab Heavy Chain, GL29H4-16 Fab Light Chain,GL29H4-16 Fab Light Chain, GLYCEROL, ... | | 著者 | Dagbay, K.B, Treece, E, Streich Jr, F.C, Jackson, J.W, Faucette, R.R, Nikiforov, A, Lin, S.C, Bostion, C.J, Nicholls, S.B, Capili, A.D, Carven, G.J. | | 登録日 | 2019-10-10 | | 公開日 | 2020-02-26 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.79 Å) | | 主引用文献 | Structural basis of specific inhibition of extracellular activation of pro- or latent myostatin by the monoclonal antibody SRK-015.
J.Biol.Chem., 295, 2020
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2YA2
 | | Catalytic Module of the Multi-modular glycogen-degrading pneumococcal virulence factor SpuA in complex with an inhibitor. | | 分子名称: | 1-DEOXYNOJIRIMYCIN, CALCIUM ION, PUTATIVE ALKALINE AMYLOPULLULANASE, ... | | 著者 | Lammerts van Bueren, A, Ficko-Blean, E, Pluvinage, B, Hehemann, J.H, Higgins, M.A, Deng, L, Ogunniyi, A.D, Stroeher, U.H, Warry, N.E, Burke, R.D, Czjzek, M, Paton, J.C, Vocadlo, D.J, Boraston, A.B. | | 登録日 | 2011-02-17 | | 公開日 | 2011-04-20 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.37 Å) | | 主引用文献 | The Conformation and Function of a Multimodular Glycogen-Degrading Pneumococcal Virulence Factor.
Structure, 19, 2011
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6UJ0
 | | Unbound BACE2 mutant structure | | 分子名称: | Beta-secretase 2, unidentified polypeptide | | 著者 | Yen, Y.C, Ghosh, A.K, Mesecar, A.D. | | 登録日 | 2019-10-01 | | 公開日 | 2020-10-07 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | A Structure-Based Discovery Platform for BACE2 and the Development of Selective BACE Inhibitors.
Acs Chem Neurosci, 12, 2021
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2YJD
 | | Stapled peptide bound to Estrogen Receptor Beta | | 分子名称: | 4-(2-PROPAN-2-YLOXYBENZIMIDAZOL-1-YL)PHENOL, ESTROGEN RECEPTOR BETA, STAPLED PEPTIDE | | 著者 | Phillips, C, Roberts, L.R, Schade, M, Bent, A, Davies, N.L, Moore, R, Pannifer, A.D, Brown, D.G, Pickford, A.R, Irving, S.L. | | 登録日 | 2011-05-19 | | 公開日 | 2011-08-03 | | 最終更新日 | 2017-01-25 | | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | | 主引用文献 | Design and Structure of Stapled Peptides Binding to Estrogen Receptors.
J.Am.Chem.Soc., 133, 2011
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1QIN
 | | HUMAN GLYOXALASE I COMPLEXED WITH S-(N-HYDROXY-N-P-IODOPHENYLCARBAMOYL) GLUTATHIONE | | 分子名称: | PROTEIN (LACTOYLGLUTATHIONE LYASE), S-(N-HYDROXY-N-IODOPHENYLCARBAMOYL)GLUTATHIONE, ZINC ION | | 著者 | Cameron, A.D, Ridderstrom, M, Olin, B, Mannervik, B. | | 登録日 | 1999-06-14 | | 公開日 | 1999-11-24 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Reaction mechanism of glyoxalase I explored by an X-ray crystallographic analysis of the human enzyme in complex with a transition state analogue.
Biochemistry, 38, 1999
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6UJ1
 | | BACE2 mutant in complex with a macrocyclic compound | | 分子名称: | (3S)-3-hydroxy-N-(2-methylpropyl)-N~2~-{[(4S)-17-[(methylsulfonyl)(propyl)amino]-2-oxo-3-azatricyclo[13.3.1.1~6,10~]icosa-1(19),6(20),7,9,15,17-hexaen-4-yl]methyl}-L-norleucinamide, Beta-secretase 2 | | 著者 | Yen, Y.C, Ghosh, A.K, Mesecar, A.D. | | 登録日 | 2019-10-02 | | 公開日 | 2020-10-07 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (3.03 Å) | | 主引用文献 | A Structure-Based Discovery Platform for BACE2 and the Development of Selective BACE Inhibitors.
Acs Chem Neurosci, 12, 2021
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6UXO
 | | Crystal structure of BAK core domain BH3-groove-dimer in complex with DDM | | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, Bcl-2 homologous antagonist/killer, ... | | 著者 | Cowan, A.D, Colman, P.M, Czabotar, P.E. | | 登録日 | 2019-11-07 | | 公開日 | 2020-09-02 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.799 Å) | | 主引用文献 | BAK core dimers bind lipids and can be bridged by them.
Nat.Struct.Mol.Biol., 27, 2020
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6VGY
 | | 2.05 A resolution structure of MERS 3CL protease in complex with inhibitor 6b | | 分子名称: | N~2~-{[(trans-4-ethylcyclohexyl)oxy]carbonyl}-N-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-leucinamide, Orf1a protein | | 著者 | Lovell, S, Battaile, K.P, Kashipathy, M.M, Rathnayake, A.D, Zheng, J, Kim, Y, Nguyen, H.N, Chang, K.O, Groutas, W.C. | | 登録日 | 2020-01-09 | | 公開日 | 2020-08-12 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | 3C-like protease inhibitors block coronavirus replication in vitro and improve survival in MERS-CoV-infected mice.
Sci Transl Med, 12, 2020
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6UXQ
 | | Crystal structure of BAK core domain BH3-groove-dimer in complex with POPC and C8E4 | | 分子名称: | (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, 1,2-ETHANEDIOL, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, ... | | 著者 | Cowan, A.D, Colman, P.M, Czabotar, P.E. | | 登録日 | 2019-11-07 | | 公開日 | 2020-09-02 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.696 Å) | | 主引用文献 | BAK core dimers bind lipids and can be bridged by them.
Nat.Struct.Mol.Biol., 27, 2020
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