 | | PRD_000187 | | Name: | SCYPTOLIN A | | Formula: | C45 H71 Cl N8 O14 | | Definition date: | 2012-12-12 | | Last modified: | 2023-09-20 |
|
 | | PRD_000195 | | Name: | Cinnamycin | | Formula: | C89 H127 N25 O25 S3 | | Description: | CINNAMYCIN IS A TETRACYCLIC PEPTIDE. POST TRANSLATIONAL MATURATION
OF LANTIBIOTICS INVOLVES THE ENZYMIC CONVERSION OF THR AND SER INTO
DEHYDRATED AMINO ACIDS AND THE FORMATION OF THIOETHER BONDS WITH
CYSTEINE. THE 14-19 BETA-METHYLLANTHIONINE THIOETHER BOND IS OXIDIZED
TO A SULFOXIDE. THE THIOETHER BONDS WITH CYSTEINE RESULT IN THREE
RING STRUCTURES, CROSSLINK BETWEEN SER AND LYS RESULT IN THE FOURTH
RING. THIS IS FOLLOWED BY MEMBRANE TRANSLOCATION AND CLEAVAGE OF THE
MODIFIED PRECURSOR. | | Definition date: | 2012-12-12 | | Last modified: | 2023-09-20 |
|
 | | PRD_000196 | | Name: | EPILANCIN 15X | | Formula: | C145 H241 N41 O33 S3 | | Description: | Epilancin 15X is a tricyclic peptide. thioether bonds with cysteine
result in three rings along the peptide chain. Post Translational
maturation of lantibiotics involves the enzymic conversion of Thr and
Ser into dehydrated amino acids and the formation of thioether bonds
with cysteine. This is followed by membrane translocation and
cleavage of the modified precursor. | | Definition date: | 2012-12-12 | | Last modified: | 2023-09-20 |
|
 | | PRD_000200 | | Name: | Nisin A | | Formula: | C141 H233 N41 O38 S7 | | Description: | Nisin Z is a heptacyclic peptide. Post Translational maturation of
lantibiotics involves the enzymic conversion of Thr, and Ser into
dehydrated AA and the formation of thioether bonds with cysteine.
Thioether bonds with cysteine result in five cyclic structures along
the peptide chain. This is followed by membrane translocation and
cleavage of the modified precursor. | | Definition date: | 2012-12-12 | | Last modified: | 2023-09-20 |
|
 | | PRD_000201 | | Name: | Alpha-Amanitin | | Formula: | C39 H54 N10 O14 S | | Description: | ALPHA-AMANITIN, IS AN 8 AMINO-ACID PEPTIDE.
THE OUTER LOOP IS FORMED BY A PEPTIDE BOND
BETWEEN THE C- AND THE N-TERMINI. THE SIDE-CHAINS
OF RESIDUES 2 AND 8 ARE LINKED TO FORM THE INNER
LOOP. | | Definition date: | 2012-12-12 | | Last modified: | 2023-09-20 |
|
 | | PRD_000217 | | Name: | Daptomycin | | Formula: | C72 H101 N17 O26 | | Description: |
DAPTOMYCIN IS AN ACIDIC CYCLIC LIPOPEPTIDE.
THE SCAFFOLD IS MADE OF TWO PARTS:
(1) THREE RESIDUES N-TERM EXOCYCLIC PART
(2) A DECAPEPTIDE LACTONE RING DERIVED FROM
CYCLISATION OF THR3 SIDE CHAIN ONTO THE C-TER
CARBOXYL GROUP
THE N-DECANOYL FATTY ACID IS LINKED TO THE
MAIN BODY OF THE MOLECULE VIA N-TERM ACYLATION. | | Definition date: | 2012-12-12 | | Last modified: | 2023-09-20 |
|
 | | PRD_000220 | | Name: | FEGLYMYCIN | | Formula: | C95 H97 N13 O30 | | Description: | FEGLYMYCIN IS A LINEAR HELICAL TRIDECAMER PEPTIDE | | Definition date: | 2012-12-12 | | Last modified: | 2023-09-20 |
|
 | | PRD_000221 | | Name: | Nosiheptide | | Formula: | C51 H46 N13 O11 S6 | | Description: | NOSIHEPTIDE IS A HETROCYCLIC THIOPEPTIDE, CONSISTING OF FIVE THIAZOLES AND ONE 3-HYDROXYPYRIDINE RINGS. A MODIFIED
INDOLE RING NO1(14) IS LINKED VIA THE SIDE CHAINS OF 3-HYDROXY 3GL(6) AND CYS(8). THE OBSERVED C-TERMINAL AMINO GROUP
NH2(13) IS LIKELY TO BE A POST-TRANSLATIONAL DECARBOXYLATED REMNANT OF A SER C-TERMINAL RESIDUE | | Definition date: | 2012-12-12 | | Last modified: | 2023-09-20 |
|
 | | PRD_000223 | | Name: | THIOSTREPTON | | Formula: | C72 H84 N19 O18 S5 | | Description: | Thiostrepton is a hetrocyclic thiopeptide belonging to the
thiocillin family, consisting of four thiazole, one thiozoline and one
piperideine rings. A modified quinoline linked to main-chain residue 1
and side-chain of residue 12. Post translational maturation of
thiazole and oxazole containing antibiotics involves the enzymic
condensation of a Cys or Ser with the alpha-carbonyl of the preceding
amino acid to form a thioether or ether bond, then dehydration to form
a double bond with the alpha-amino nitrogen. Thiazoline or oxazoline
ring are dehydrogenated to form thiazole or oxazole rings. the
pyridinyl involves the cross-linking of a Ser and a Cys-Ser pair
usually separated by 7 or 8 residues along the peptide chain. The Ser
residues are dehydrated to didehydroalanines, then bonded between
their beta carbons. The alpha carbonyl of the Cys condenses with alpha
carbon of the first Ser to form a pyridinyl ring. The ring may be
mutiply dehydrogenated to form a pyridine ring with loss of the amino
nitrogen of the first Ser. The amidation of Ser-17 probably does not
occur by the same mechanism, oxidative cleavage of glycine, as in
eukaryotes. | | Definition date: | 2012-12-12 | | Last modified: | 2023-09-20 |
|
 | | PRD_000225 | | Name: | GE2270a | | Formula: | C56 H58 N15 O10 S6 | | Description: | GEA2270A IS A THIOPEPTIDE CONSISTING OF ONE
PYRIDINE, ONE OXAZOLE AND FIVE THIAZOLE RINGS.
THE OBSERVED C-TERMINAL AMINO GROUP NH2(15) IS
LIKELY TO BE A POST-TRANSLATIONAL DECARBOXYLATED
REMNANT OF A SER C-TERMINAL RESIDUE. | | Definition date: | 2012-12-12 | | Last modified: | 2023-09-20 |
|
 | | PRD_000228 | | Name: | JG-365 | | Formula: | C42 H68 N8 O11 | | Definition date: | 2012-12-12 | | Last modified: | 2023-09-20 |
|
 | | PRD_000379 | | Name: | N-acetylated chloromethylated fibrinopeptide A | | Formula: | C47 H75 Cl N13 O15 | | Definition date: | 2012-12-12 | | Last modified: | 2023-09-20 |
|
 | | PRD_000396 | | Name: | N-{(2S)-2-[{N-acetyl-3-cyclohexyl-L-alanyl-N~5~-[amino(iminio)methyl]-L-ornithyl}(methyl)amino]-2-phenylacetyl}-L-methionyl-L-alanyl-L-seryl-3-methyl-L-valinamide | | Formula: | C43 H72 N11 O9 S | | Definition date: | 2012-12-12 | | Last modified: | 2023-09-20 |
|
 | | PRD_000429 | | Name: | (ACE)APQV(STA)VMHP peptide Inhibitor | | Formula: | C49 H81 N12 O13 S | | Definition date: | 2012-12-12 | | Last modified: | 2023-09-20 |
|
 | | PRD_000483 | | Name: | Bacillomycin Lc | | Formula: | C47 H74 N10 O16 | | Description: | BACILLOMYCIN LC IS A CYCLIC HEPTA-LIPOPETIDE
WITH 7 AMINO-ACIDS OF CONFIGURATION LDDLLDL AND
ONE D-BETA-AMINO CARBOXYLIC ACID.
THE FATTY ACID IS LINKED VIA A PEPTID BOND
TO BOTH RESIDUES 2 AND 8. | | Definition date: | 2012-12-12 | | Last modified: | 2023-09-20 |
|
 | | PRD_000484 | | Name: | Balhimycin | | Formula: | C66 H75 Cl2 N9 O25 | | Description: | BALHIMYCIN IS A TRICYCLIC HEPTAPEPTIDE GLYCOSYLATED BY D-GLUCOSE (RESIDUE 8) ON RESIDUE 4 AND BY 4-OXO-VANCOSAMINE
(RESIDUE 9) ON RESIDUE 6. | | Definition date: | 2012-12-12 | | Last modified: | 2023-09-20 |
|
 | | PRD_000485 | | Name: | Deglucobalhimycin | | Formula: | C60 H65 Cl2 N9 O20 | | Description: | DEGLUCOBALHIMYCIN LACKS THE D-GLUCOSE COMPONENT OF BALHIMYCIN CONSISTING OF THE TRICYCLIC HEPTAPEPTIDE AND
(2R,4S,6S)-4-AZANYL-4,6-DIMETHYL-OXANE-2,5,5-TRIOL ONLY LINKED TO RESIDUE 6. | | Definition date: | 2012-12-12 | | Last modified: | 2023-09-20 |
|
 | | PRD_000487 | | Name: | Tsushimycin | | Formula: | C59 H93 N13 O20 | | Description: | TSUSHIMYCIN IS A CYCLIC LIPOPEPTIDE.
THE SCAFFOLD IS MADE OF TWO PARTS:
(1) ASP1 N-TERM EXOCYCLIC PART
(2) A DECAPEPTIDE RING. RESIDUE 2 AND 11 FORM
A PEPTIDE BOND.
A TETRADECENOIC FATTY ACID IS LINKED TO THE
RESIDUE 1 | | Definition date: | 2012-12-12 | | Last modified: | 2023-09-20 |
|
 | | PRD_000488 | | Name: | TRIOSTIN A | | Formula: | C50 H62 N12 O12 S2 | | Description: | TRIOSTIN IS A BICYCLIC OCTADEPSIPEPTIDE.
BICYCLIZATION IS ACHIEVED BY LINKING THE N- AND
THE C- TERMINI, AND A DISULPHIDE BOND BETWEEN
RESIDUES 3 AND 7.
THE TWO QUINOXALINE CHROMOPHORES ARE LINKED
TO THE D-SERINE RESIDUES, RESIDUES 1 AND 5. | | Definition date: | 2012-12-12 | | Last modified: | 2023-09-20 |
|
 | | PRD_000491 | | Name: | Echinomycin | | Formula: | C51 H64 N12 O12 S2 | | Description: | ECHINOMYCIN IS A BICYCLIC OCTADEPSIPEPTIDE.
BICYCLIZATION IS ACHIEVED BY LINKING THE N- AND
THE C- TERMINI, AND A THIOACETAL BOND BETWEEN
RESIDUES 3 AND 7.
THE TWO QUINOXALINE CHROMOPHORES ARE LINKED
TO THE D-SERINE RESIDUES, RESIDUES 1 AND 5. | | Definition date: | 2012-12-12 | | Last modified: | 2023-09-20 |
|
 | | PRD_000492 | | Name: | uk63052 | | Formula: | C56 H68 N10 O14 S2 | | Description: | QUINOMYCIN UK63052 IS A BICYCLIC OCTADEPSIPEPTIDE.
BICYCLIZATION IS ACHIEVED BY LINKING THE N- AND
THE C- TERMINI, AND A THIOACETAL BOND BETWEEN
RESIDUES 3 AND 7.
THE TWO HYDROXYQUINOXALINE CHROMOPHORES ARE LINKED
TO THE D-SERINE RESIDUES, RESIDUES 1 AND 5. | | Definition date: | 2012-12-12 | | Last modified: | 2023-09-20 |
|
 | | PRD_000505 | | Name: | Quinupristin | | Formula: | C53 H67 N9 O10 S | | Description: | QUINUPRISTIN IS A CYLIC HEPTAPEPTIDE. THE RING GENERATED BY LINKING RESIDUE 2 SIDE-CHAIN IS AND MAIN-CHAIN RESIDUE 7. | | Definition date: | 2012-12-12 | | Last modified: | 2023-09-20 |
|
 | | PRD_000507 | | Name: | PYOVERDIN C-E CHROMOPHORE | | Formula: | C55 H86 N17 O22 | | Description: | IN IRON-DEFICIENT CONDITIONS, PSEUDOMONAS AERUGINOSA SECRETES A MAJOR FLUORESCENT SIDEROPHORE NAMED PYOVERDIN (PVD),
WHICH AFTER CHELATING IRON(III) IS TRANSPORTED BACK INTO THE CELL VIA ITS OUTER MEMBRANE RECEPTOR FPVA. FPVA IS A
TONB-DEPENDENT TRANSPORT PROTEIN AND HAS THE ABILITY TO BIND PVD IN ITS APO- OR IRON-LOADED FORM. | | Definition date: | 2012-12-12 | | Last modified: | 2023-09-20 |
|
 | | PRD_000720 | | Name: | BACILLOMYCIN L-3 | | Formula: | C35 H50 N10 O16 | | Description: | BACILLOMYCIN ANALOGUE IS A CYCLIC HEPTA-LIPOPEPTIDE
WITH 8 AMINO-ACIDS OF CONFIGURATION LLDDLLDL
THE BETA-ALANINE IS LINKED VIA A PEPTIDE BOND
TO BOTH RESIDUES 2 AND 8. | | Definition date: | 2012-12-12 | | Last modified: | 2023-09-20 |
|
 | | PRD_000723 | | Name: | PYOVERDIN C-E Fe Complex | | Formula: | C55 H82 Fe N17 O22 | | Description: | IN IRON-DEFICIENT CONDITIONS, PSEUDOMONAS
AERUGINOSA SECRETES A MAJOR FLUORESCENT
SIDEROPHORE NAMED PYOVERDIN (PVD),
WHICH AFTER CHELATING IRON(III) IS TRANSPORTED
BACK INTO THE CELL VIA ITS OUTER MEMBRANE RECEPTOR
FPVA. FPVA IS A TONB-DEPENDENT TRANSPORT PROTEIN
AND HAS THE ABILITY TO BIND PVD IN ITS APO-
OR IRON-LOADED FORM. | | Definition date: | 2012-12-12 | | Last modified: | 2023-09-20 |
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