9TFF

KIT kinase domain in complex with a pyrrolopyrimidine-based compound (17)

これはPDB形式変換不可エントリーです。

9TFF の概要

• エントリーDOI: 10.2210/pdb9tff/pdb
• 分子名称: Mast/stem cell growth factor receptor Kit, 4-[4-[5-(phenylmethyl)pyrimidin-2-yl]piperazin-1-yl]-7~{H}-pyrrolo[2,3-d]pyrimidine (3 entities in total)
• 機能のキーワード: kit protein kinase, inhibitor, tyrosine kinase, transmembrane receptor, stem cell factor, scf, stem cell factor receptor, gist, gastrointestinal stromal tumors, p10721, transferase
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 75131.74

構造登録者

Scrima, A.,Mueller, M.P.,Rauh, D. (登録日: 2025-11-27, 公開日: 2026-07-15)

• 主引用文献: Schulz, T.,Beerbaum, M.,Scrima, A.,Jantzen, H.,Teuber, A.,Muehlenberg, T.,Garcia-Fossa, F.,Weisner, J.,Mueller, M.P.,Sievers, S.,Bauer, S.,Rauh, D.; Structure-based Scaffold Hopping Reveals Strategies to Overcome Oncogenic KIT and PDGFRA Mutation-Driven Drug-Resistance in GIST; To Be Published,

実験手法

X-RAY DIFFRACTION (1.8 Å)