9TFA

PDGFRA-G680R mutant kinase domain in complex with a 6,7-dimethoxyquinazoline-based compound (43)

これはPDB形式変換不可エントリーです。

9TFA の概要

• エントリーDOI: 10.2210/pdb9tfa/pdb
• 分子名称: Platelet-derived growth factor receptor alpha, (1~{S})-1-[2-[4-(6,7-dimethoxyquinazolin-4-yl)piperazin-1-yl]pyrimidin-5-yl]-1-(4-fluorophenyl)ethanamine (3 entities in total)
• 機能のキーワード: pdgfra protein kinase, inhibitor, tyrosine kinase, transmembrane receptor, platelet-derived growth factor receptor alpha, pdgf, platelet-derived growth factor, gist, gastrointestinal stromal tumors, solvent-front mutant, p16234, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 41075.30

構造登録者

Scrima, A.,Mueller, M.P.,Rauh, D. (登録日: 2025-11-27, 公開日: 2026-07-15)

• 主引用文献: Schulz, T.,Beerbaum, M.,Scrima, A.,Jantzen, H.,Teuber, A.,Muehlenberg, T.,Garcia-Fossa, F.,Weisner, J.,Mueller, M.P.,Sievers, S.,Bauer, S.,Rauh, D.; Structure-based Scaffold Hopping Reveals Strategies to Overcome Oncogenic KIT and PDGFRA Mutation-Driven Drug-Resistance in GIST; To Be Published,

実験手法

X-RAY DIFFRACTION (2.2 Å)