9TCB

Catalytic domain of human PARP15 in complex with BAD

9TCB の概要

• エントリーDOI: 10.2210/pdb9tcb/pdb
• 分子名称: Protein mono-ADP-ribosyltransferase PARP15, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl [(2R,3S,4R,5S)-5-(3-carbamoylphenyl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate (non-preferred name), NICOTINAMIDE, ... (4 entities in total)
• 機能のキーワード: adp-ribosylation, adp-ribosyltransferase, artd, parp, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 46720.13

構造登録者

Paakkonen, J.,Lehtio, L. (登録日: 2025-11-21, 公開日: 2026-01-28)

• 主引用文献: Tuovinen, A.,Paakkonen, J.,Maksimainen, M.M.,Hirschen, L.,Hentila, H.I.,Tauscher, M.,Luscher, B.,Vela-Rodriguez, C.,Korn, P.,Lehtio, L.; Dimerization of human PARP15 is required for NAD+ binding and automodification; Biorxiv, 2025; DOI: 10.64898/2025.12.15.694324

実験手法

X-RAY DIFFRACTION (1.9 Å)