9T3Q

Crystal structure of D1228V c-MET bound by cabozantinib.

これはPDB形式変換不可エントリーです。

9T3Q の概要

• エントリーDOI: 10.2210/pdb9t3q/pdb
• 分子名称: Hepatocyte growth factor receptor, Cabozantinib (3 entities in total)
• 機能のキーワード: kinase, c-met, drug discovery, cancer, nsclc, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35327.87

構造登録者

Collie, G.W.,Russell, I.C. (登録日: 2025-10-28, 公開日: 2026-02-18, 最終更新日: 2026-04-01)

主引用文献

Russell, I.C.,Bachurska-Szpala, P.,van Beek, L.,Michaelides, I.N.,Phillips, C.,Snijder, A.,Stubbs, C.J.,Collie, G.W.
Molecular Basis of c‐MET Inhibition by Approved Small Molecule Drugs: A Structural Perspective.
Acs Med.Chem.Lett., 17:590-597, 2026

PubMed Abstract: The c-MET kinase is a driver of many cancers, and as such, there are a number of small molecule inhibitors of this kinase approved for clinical use. In this Microperspective, we provide a structural overview of the molecular basis by which these drugs inhibit c-MET, focusing on key features contributing to activity, selectivity, and drug resistance. Where necessary, relevant crystal structures not publicly available were determined and are discussed here alongside existing structural data.

PubMed: 41847658
DOI: 10.1021/acsmedchemlett.5c00713

実験手法

X-RAY DIFFRACTION (1.629 Å)