9SPR

p53 cancer mutant R282W in complex with DARPin C10

9SPR の概要

• エントリーDOI: 10.2210/pdb9spr/pdb
• 分子名称: Cellular tumor antigen p53, DARPin C10, ZINC ION, ... (5 entities in total)
• 機能のキーワード: p53, tumor suppressor, cancer mutation, protein stability, protein unfolding disease, designed ankyrin repeat proteins, thermostabilization, mutant p53 reactivation, cancer therapy, transcription
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 36715.88

構造登録者

Balourdas, D.I.,Muenick, P.,Knapp, S.,Dotsch, V.,Joerger, A.C.,Structural Genomics Consortium (SGC) (登録日: 2025-09-17, 公開日: 2026-04-22)

• 主引用文献: Balourdas, D.I.,Muenick, P.,Knapp, S.,Dotsch, V.,Joerger, A.C.,Structural Genomics Consortium (SGC); p53 cancer mutant R282W in complex with DARPin C10; to be published,

実験手法

X-RAY DIFFRACTION (1.66 Å)