9RL6

Structure Guided Optimisation of Niclosamide Derivatives as Direct STAT3 Inhibitors Targeting a Novel Binding Site

9RL6 の概要

• エントリーDOI: 10.2210/pdb9rl6/pdb
• 分子名称: DNA (5'-D(*TP*GP*CP*AP*TP*TP*TP*CP*CP*CP*GP*TP*AP*AP*AP*TP*CP*T)-3'), Isoform Stat3B of Signal transducer and activator of transcription 3, 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide, ... (4 entities in total)
• 機能のキーワード: sh2 domain, protein dna complex, signal transducer, activator of transcription, duplex dna, nucleus, cytosol, transcription-dna complex, dna binding protein
• 由来する生物種: Mus musculus (house mouse); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 73903.78

構造登録者

Quamruzzaman, M.,Maneshi, P.,Knight, R.,Parkinson, G.N.,Wells, G. (登録日: 2025-06-16, 公開日: 2026-06-24)

• 主引用文献: Quamruzzaman, M.,Maneshi, P.,Knight, R.,Parkinson, G.N.,Wells, G.; Structure Guided Optimisation of Niclosamide Derivatives as Direct STAT3 Inhibitors Targeting a Novel Binding Site; To Be Published,

実験手法

X-RAY DIFFRACTION (2.55 Å)