9R4Z

Murine AA amyloid fibril morphology III (AA III)

9R4Z の概要

• エントリーDOI: 10.2210/pdb9r4z/pdb
• EMDBエントリー: 53573
• 分子名称: Serum amyloid A-2 protein (1 entity in total)
• 機能のキーワード: amyloid fibril, aa amyloidosis, systemic amyloidosis, aapoaii amyloidosis, misfolfing disease, protein aggregation, protein fibril
• 由来する生物種: Mus musculus (house mouse)
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 139471.55

構造登録者

Andreotti, G.,Schmidt, M.,Faendrich, M. (登録日: 2025-05-08, 公開日: 2025-10-01)

主引用文献

Andreotti, G.,Higuchi, K.,Schmidt, M.,Fandrich, M.
Cryo-EM observation of AA amyloid fibrils in mouse model of systemic AApoAII amyloidosis.
J.Mol.Biol., :169438-169438, 2025

PubMed Abstract: The co-deposition of amyloid fibrils from different precursor proteins is a topic of increasing relevance for protein misfolding diseases. Using cryo-electron microscopy (cryo-EM), we here determined the structures of two serum amyloid A (SAA) protein-derived amyloid fibril morphologies that were extracted from a mouse strain that is primarily known to be associated with apolipoprotein A-II-derived amyloid fibrils. The two fibril morphologies show the same protomer conformation as in previously reported ex vivo amyloid fibrils from SAA protein but a different relative arrangement of fibril protein stacks. These data establish that serum amyloid A-derived amyloid fibrils share the same fibril protein fold in different mouse strains and disease contexts.

PubMed: 40945578
DOI: 10.1016/j.jmb.2025.169438

実験手法

ELECTRON MICROSCOPY (3.5 Å)