9R3C

Recombinant human butyrylcholinesterase in complex with N-([(3S)-1-benzylpiperidin-3-yl]methyl)-N-(2-methoxyethyl)naphthalene-2-sulfonamide

Summary for 9R3C

• Entry DOI: 10.2210/pdb9r3c/pdb
• Descriptor: Cholinesterase, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
• Functional Keywords: butyrylcholinesterase, inhibitor, complex, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 63302.04

Authors

Brazzolotto, X.,Kosak, U.,Gobec, S.,Nachon, F. (deposition date: 2025-05-03, release date: 2025-07-30)

• Primary citation: Kosak, U.,Knez, D.,Benetik, S.F.,Sokolov, P.M.,Pislar, A.,Horvat, S.,Stojan, J.,Lv, B.,Zhang, W.,Wang, Y.,Wang, Q.,Igert, A.,Dias, J.,Nachon, F.,Brazzolotto, X.,Sun, H.,Gobec, S.; Chiral switch of a butyrylcholinesterase inhibitor for the treatment of Alzheimer's disease; Chem.Biol.Interact., :111670-, 2025; DOI: 10.1016/j.cbi.2025.111670

Experimental method

X-RAY DIFFRACTION (2.31 Å)