9QT6

Crystal structure of HPK1 T165E/S171E in complex with pyrazine carboxamide inhibitor

This is a non-PDB format compatible entry.

Summary for 9QT6

• Entry DOI: 10.2210/pdb9qt6/pdb
• Descriptor: Mitogen-activated protein kinase kinase kinase kinase 1, 3-[(1,3-dimethylpyrazol-4-yl)amino]-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxamide, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 33402.71

Authors

Schimpl, M. (deposition date: 2025-04-08, release date: 2025-05-28)

• Primary citation: Metrano, A.J.; Synthetic Chemistry Driving the Discovery and Development of a Series of Pyrazoles as HPK1 Inhibitors; To be published,

Experimental method

X-RAY DIFFRACTION (1.76 Å)