9Q4X

Structure of human endothelial nitric oxide synthase heme domain bound with 6-((5-(2-(dimethylamino)ethyl)-2,3-difluorophenoxy)methyl)-4-methylpyridin-2-amine

This is a non-PDB format compatible entry.

Summary for 9Q4X

• Entry DOI: 10.2210/pdb9q4x/pdb
• Descriptor: Nitric oxide synthase 3, CALCIUM ION, PROTOPORPHYRIN IX CONTAINING FE, ... (11 entities in total)
• Functional Keywords: nitric oxide synthase inhibitor binding, oxidoreductase-inhibitor complex, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 205307.75

Authors

Li, H.,Poulos, T.L. (deposition date: 2025-08-20, release date: 2025-09-10)

• Primary citation: Ansari, A.,Chrzanowski, R.T.,Li, H.,Hardy, C.D.,Poulos, T.L.,Silverman, R.B.; Highly potent, selective, and membrane permeable ether linked 2-aminopyridine-based human neuronal nitric oxide synthase inhibitors; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.15 Å)