9PQD

Locally-refined structure of alpha2a adrenergic receptor in complex with Go heterotrimer, scFv16, and compound Z7149

This is a non-PDB format compatible entry.

Summary for 9PQD

• Entry DOI: 10.2210/pdb9pqd/pdb
• EMDB information: 71783
• Descriptor: Alpha-2A adrenergic receptor, (6M)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1H-indole (2 entities in total)
• Functional Keywords: gpcr, complex, drug, small molecule, polypharmacology, membrane protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 53856.15

Authors

Srinivasan, K.,Wu, Y.,Billesboelle, C.,Kim, J.Y.,Manglik, A.,Shoichet, B.K. (deposition date: 2025-07-22, release date: 2025-08-20)

• Primary citation: Wu, Y.,Vigneron, S.,Huang, X.,Braz, J.,Srinivasan, K.,Fink, E.,Xu, X.,Huebner, H.,Billesboelle, C.,Kim, J.Y.,Wang, J.,Pfeiffer, T.,Sakamoto, K.,Radchenko, D.,Moroz, Y.,Irwin, J.,Gmeiner, P.,Roth, B.,Basbaum, A.,Manglik, A.,Wetsel, W.,Shoichet, B.K.; Large library docking for polypharmacology; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3.29 Å)