9PPU

Beta-sandwich forming metallopeptide

9PPU の概要

• エントリーDOI: 10.2210/pdb9ppu/pdb
• 分子名称: De novo designed metallopeptide, COPPER (II) ION, FORMIC ACID, ... (6 entities in total)
• 機能のキーワード: beta-sandwich, copper, metallopeptide, de novo protein
• 由来する生物種: synthetic construct; 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 3548.96

構造登録者

Dang, V.T.,Nguyen, A.I. (登録日: 2025-07-21, 公開日: 2026-04-22, 最終更新日: 2026-04-29)

主引用文献

Dang, V.T.,Drena, A.,Telser, J.,Wofford, L.,Nguyen, A.I.
A bis-macrocylic peptide ligand mimicking the beta-sandwich active site of multicopper oxidases.
Dalton Trans, 55:5877-5881, 2026

PubMed Abstract: The active site of multicopper oxidases contains three Cu ions coordinated to a β-sandwich motif. Here, we designed a small peptide ligand that closely mimics the β-sandwich. We verified the sandwich architecture by X-ray crystallography, showing its high resemblance to the active site and ability to coordinate two Cu(II) ions.

PubMed: 41969027
DOI: 10.1039/d6dt00494f

実験手法

X-RAY DIFFRACTION (1.49 Å)