9OMP

mGluR7 in native membrane vesicles

9OMP の概要

• エントリーDOI: 10.2210/pdb9omp/pdb
• EMDBエントリー: 70615
• 分子名称: Metabotropic glutamate receptor 7 (1 entity in total)
• 機能のキーワード: gpcr, class c, membrane protein, cluster
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 205669.88

構造登録者

Mandala, V.,Fu, Z.,MacKinnon, R. (登録日: 2025-05-14, 公開日: 2025-07-09)

主引用文献

Mandala, V.S.,Fu, Z.,MacKinnon, R.
Molecular contacts in self-assembling clusters of membrane proteins.
Proc.Natl.Acad.Sci.USA, 122:e2507112122-e2507112122, 2025

PubMed Abstract: Motivated by recent data pointing to the existence of homo-oligomeric assemblies of membrane proteins called higher-order transient structures, and their apparent role in connecting components of membrane signal pathways, we examine here by cryoelectron microscopy some of the protein-protein interactions that occur in cluster formation. Metabotropic glutamate receptors and HCN ion channels inside clusters contact their neighbors through structured extracellular and intracellular domains, respectively. Other ion channels, including Kv2.1 and Slo1, appear to form clusters through prominent intrinsically disordered sequences in the cytoplasm. These distinct modes of interaction are associated with clusters exhibiting varying degrees of compactness and order. We conclude that nature utilizes a variety of ways to form connections between membrane proteins in self-assembled clusters.

PubMed: 40549920
DOI: 10.1073/pnas.2507112122

実験手法

ELECTRON MICROSCOPY (4.3 Å)