9OCF

2.73A cryo-EM structure of the Measles Virus L-P in complex with ERdRp-0519

This is a non-PDB format compatible entry.

Summary for 9OCF

• Entry DOI: 10.2210/pdb9ocf/pdb
• EMDB information: 70313
• Descriptor: RNA-directed RNA polymerase L, Phosphoprotein, 2-methyl-~{N}-[4-[(2~{S})-2-(2-morpholin-4-ylethyl)piperidin-1-yl]sulfonylphenyl]-5-(trifluoromethyl)pyrazole-3-carboxamide (3 entities in total)
• Functional Keywords: measles virus, l protein, phosphoprotein, rna-dependent rna polymerase, prntase, gdp polyribonucleotidyl transferase, rna capping, mtase, viral replication, viral protein, transferase, erdrp-0519
• Biological source: Measles virus strain Edmonston-B; More
• Total number of polymer chains: 5
• Total formula weight: 464793.55

Authors

Liu, B.,Wang, D.,Yang, G. (deposition date: 2025-04-24, release date: 2025-09-03, Last modification date: 2025-10-22)

• Primary citation: Liu, B.,Wang, D.,Yang, G.; Structural basis of measles virus polymerase inhibition by nonnucleoside inhibitor ERDRP-0519; Nat Commun, 16:9061-, 2025

Experimental method

ELECTRON MICROSCOPY (2.73 Å)