9OCE

2.48A cryo-EM structure of the Measles Virus L-P-C in complex with ERdRp-0519

これはPDB形式変換不可エントリーです。

9OCE の概要

• エントリーDOI: 10.2210/pdb9oce/pdb
• EMDBエントリー: 70312
• 分子名称: RNA-directed RNA polymerase L, Phosphoprotein, Protein C, ... (4 entities in total)
• 機能のキーワード: measles virus, l protein, phosphoprotein, rna-dependent rna polymerase, prntase, gdp polyribonucleotidyl transferase, rna capping, mtase, viral replication, viral protein, transferase, c protein, erdrp-0519
• 由来する生物種: Measles virus strain Edmonston-B; 詳細
• タンパク質・核酸の鎖数: 7
• 化学式量合計: 506926.28

構造登録者

Liu, B.,Wang, D.,Yang, G. (登録日: 2025-04-24, 公開日: 2025-09-03, 最終更新日: 2025-10-29)

主引用文献

Wang, D.,Bu, F.,Yang, G.,Liu, B.
Structural basis of measles virus polymerase inhibition by nonnucleoside inhibitor ERDRP-0519.
Nat Commun, 16:9061-9061, 2025

PubMed Abstract: ERDRP-0519 is a potent nonnucleoside inhibitor active against measles virus (MeV) and other Morbilliviruses. Here we report cryo-EM structures of the compound bound to MeV polymerase complexes at 2.73 Å and 2.48 Å resolution, revealing a unique binding pocket in the RdRp palm subdomain that overlaps the catalytic GDN motif. These findings clarify the basis of resistance mutations, including W671, and provide a foundation for designing next-generation Paramyxovirus antivirals.

PubMed: 41083444
DOI: 10.1038/s41467-025-64128-0

実験手法

ELECTRON MICROSCOPY (2.48 Å)