9O9C

Structure of the IL-18 Surrogate Cytokine Agonist DR3085

Summary for 9O9C

Entry DOI	10.2210/pdb9o9c/pdb
Descriptor	IL-18 Surrogate Cytokine Agonist DR3085 (1 entity in total)
Functional Keywords	surrogate cytokine agonist, dual-vhh, protein binding
Biological source	Lama glama (llama)
Total number of polymer chains	2
Total formula weight	53054.80
Authors	Trenker, R.,Vivona, S.,Lupardus, P.J. (deposition date: 2025-04-17, release date: 2025-09-10, Last modification date: 2025-10-08)
Primary citation	Trenker, R.,Rokkam, D.,Morin, A.,Balasubrahmanyam, P.,Paredes, V.,Cheng, I.,de Waal Malefyt, R.,Oft, M.,Lupardus, P.,Vivona, S. Structure-Guided Stapling of Dimeric Conformations and Linker Engineering Enhance Thermostability and Fine-Tune Activity of Bispecific VHH Cytokine Agonists. Antibodies, 14:-, 2025 Cited by PubMed Abstract: Bispecific antibodies have emerged as a promising class of therapeutics, enabling simultaneous targeting of two distinct antigens. Single-domain antibodies (sdAbs) comprising camelid variable heavy chains (VHHs) provide a compact and adaptable platform for bispecific antibody design due to their small size and ease of linkage. PubMed: 40981273 DOI: 10.3390/antib14030074 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.8 Å)

Structure validation