9O99
Structure of the IL-2 Surrogate Cytokine Agonist DR638
Summary for 9O99
| Entry DOI | 10.2210/pdb9o99/pdb |
| Descriptor | IL-2 Surrogate Cytokine Agonist DR638 (2 entities in total) |
| Functional Keywords | surrogate cytokine agonist, dual-vhh, protein binding |
| Biological source | Lama glama (llama) |
| Total number of polymer chains | 1 |
| Total formula weight | 26945.76 |
| Authors | Trenker, R.,Vivona, S.,Lupardus, P.J. (deposition date: 2025-04-17, release date: 2025-09-10, Last modification date: 2025-10-08) |
| Primary citation | Trenker, R.,Rokkam, D.,Morin, A.,Balasubrahmanyam, P.,Paredes, V.,Cheng, I.,de Waal Malefyt, R.,Oft, M.,Lupardus, P.,Vivona, S. Structure-Guided Stapling of Dimeric Conformations and Linker Engineering Enhance Thermostability and Fine-Tune Activity of Bispecific VHH Cytokine Agonists. Antibodies, 14:-, 2025 Cited by PubMed Abstract: Bispecific antibodies have emerged as a promising class of therapeutics, enabling simultaneous targeting of two distinct antigens. Single-domain antibodies (sdAbs) comprising camelid variable heavy chains (VHHs) provide a compact and adaptable platform for bispecific antibody design due to their small size and ease of linkage. PubMed: 40981273DOI: 10.3390/antib14030074 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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