9O6E

Crystal Structure of SARS-CoV-2 Mpro S10C in complex with Pfizer Intravenous Inhibitor PF-00835231

Summary for 9O6E

• Entry DOI: 10.2210/pdb9o6e/pdb
• Descriptor: 3C-like proteinase nsp5, DIMETHYL SULFOXIDE, 1,2-ETHANEDIOL, ... (5 entities in total)
• Functional Keywords: sars2, sars-cov-2, mpro, s10c, covid19, viral protein
• Biological source: Severe acute respiratory syndrome coronavirus 2
• Total number of polymer chains: 2
• Total formula weight: 68834.59

Authors

Zvornicanin, S.N.,Shaqra, A.M.,Schiffer, C.A. (deposition date: 2025-04-13, release date: 2025-12-10)

• Primary citation: Zvornicanin, S.N.,Shaqra, A.M.,Flynn, J.,Intravaia, L.E.,Martinez, H.C.,Jia, W.,Gupta, D.K.,Moquin, S.,Dovala, D.,Bolon, D.N.,Kelch, B.A.,Schiffer, C.A.,Yilmaz, N.K.; Cooperativity and Communication between the Active Sites of the Dimeric SARS-CoV-2 Main Protease; Sci Adv, 2025

Experimental method

X-RAY DIFFRACTION (1.99 Å)