9O4B

Cryo-EM structure of in-vitro alpha-synuclein fibril bound with Exemplar-6 PET-radioligand

This is a non-PDB format compatible entry.

Summary for 9O4B

• Entry DOI: 10.2210/pdb9o4b/pdb
• EMDB information: 70093
• Descriptor: Alpha-synuclein, 2-(3,4-dimethylphenoxy)-N-[3-(4-fluorophenyl)-1,2-oxazol-5-yl]acetamide (2 entities in total)
• Functional Keywords: alpha-synuclein, fibril, amyloid, structural protein, protein fibril
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 12
• Total formula weight: 177797.47

Authors

Sanchez, J.C.,Perez, R.M.,Borcik, C.G.,Guarino, D.S.,Dhavala, D.D.,Baumgardt, J.K.,Shaffer, K.D.,Kotzbauer, P.T.,Mach, R.H.,Rienstra, C.M.,Petersson, E.J.,Wright, E.R. (deposition date: 2025-04-08, release date: 2025-04-23)

• Primary citation: Sanchez, J.C.,Perez, R.M.,Borcik, C.G.,Guarino, D.S.,Dhavala, D.D.,Baumgardt, J.K.,Shaffer, K.D.,Kotzbauer, P.T.,Mach, R.H.,Rienstra, C.M.,Petersson, E.J.,Wright, E.R.; Complementary Structural and Chemical Biology Methods Reveal the Basis for Selective Radioligand Binding to Alpha-Synuclein in MSA Tissue; To Be Published,

Experimental method

ELECTRON MICROSCOPY (2.59 Å)