9NSZ

OXA-23-NA-1-157, 6 minute soak

Summary for 9NSZ

• Entry DOI: 10.2210/pdb9nsz/pdb
• Descriptor: Beta-lactamase OXA-23, (5R)-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-5-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-5-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid, SULFATE ION, ... (5 entities in total)
• Functional Keywords: oxa, antibiotic resistance, inhibitor, na-1-157, hydrolase
• Biological source: Acinetobacter baumannii
• Total number of polymer chains: 1
• Total formula weight: 31676.48

Authors

Smith, C.A.,Toth, M.,Stewart, N.K.,Vakulenko, S.B. (deposition date: 2025-03-17, release date: 2025-08-06)

• Primary citation: Toth, M.,Stewart, N.K.,Buynak, J.D.,Smith, C.A.,Vakulenko, S.B.; Dual Mechanism of the OXA-23 Carbapenemase Inhibition via Catalytic Lysine Decarboxylation and Water Access Restriction by the Carbapenem NA-1-157; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.8 Å)