9MG3

Structure of Kluyveromyces lactis mRNA cap (guanine-N7) methyltransferase, Abd1, in complex with sinefungin and GTP

Summary for 9MG3

• Entry DOI: 10.2210/pdb9mg3/pdb
• Related: 9MG0 9MG1 9MG2
• Descriptor: mRNA cap guanine-N(7) methyltransferase, SINEFUNGIN, GUANOSINE-5'-TRIPHOSPHATE, ... (7 entities in total)
• Functional Keywords: methyltransferase, mrna, cap, sinefungin, gtp, transferase, abd1, k. lactis
• Biological source: Kluyveromyces lactis NRRL Y-1140
• Total number of polymer chains: 2
• Total formula weight: 69321.12

Authors

Nilson, D.J.,Fedorov, E.,Ghosh, A. (deposition date: 2024-12-10, release date: 2025-07-09)

• Primary citation: Nilson, D.J.,Schwer, B.,Shuman, S.,Almo, S.C.; Structural basis for sensitivity and acquired resistance of fungal cap guanine-N7 methyltransferases to the antifungal antibiotic Sinefungin; Nucleic Acids Res., 2025; DOI: 10.1093/nar/gkaf538

Experimental method

X-RAY DIFFRACTION (1.42 Å)