9MF5

CryoEM structure of the Protein Phosphatase 2A (Abeta-B56gamma-Calpha) holoenzyme complex

Summary for 9MF5

• Entry DOI: 10.2210/pdb9mf5/pdb
• EMDB information: 48224
• Descriptor: Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform, Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform, Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform, ... (4 entities in total)
• Functional Keywords: phosphatase, complex, holoenzyme, heterotrimer, signaling protein, hydrolase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 163167.90

Authors

Day, A.,Taylor, D. (deposition date: 2024-12-09, release date: 2025-07-09)

• Primary citation: Day, A.,Huang, W.,Leonard, D.,O'Connor, C.M.,Narla, G.,Ogris, E.,Taylor, D.J.; Regulatory mechanisms of PP2A complex assembly driven by physiochemical differences in A-subunit isoforms; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3.2 Å)