9M7V

Cryo-EM structure of enterovirus A71 mature virion in complex with Fab CT11F9

Summary for 9M7V

• Entry DOI: 10.2210/pdb9m7v/pdb
• EMDB information: 63694
• Descriptor: The light chain of Fab CT11F9, The heavy chain of Fab CT11F9, Capsid protein VP1, ... (7 entities in total)
• Functional Keywords: virus, enterovirus a71
• Biological source: Mus musculus; More
• Total number of polymer chains: 6
• Total formula weight: 119694.44

Authors

Jiang, Y.,Zhu, R.,Zheng, Q.,Li, S.,Xia, N. (deposition date: 2025-03-11, release date: 2025-04-23, Last modification date: 2025-05-21)

Primary citation

Zhang, X.,Yi, L.,Yu, D.,Li, J.,Li, X.,Wu, X.,Gao, F.,He, Q.,Wang, W.,Wang, K.,Wang, Z.,Liu, Z.,Li, Y.,Zhao, Y.,Li, H.,Ma, X.,Zheng, Q.,Xu, L.,Cheng, T.,Zhu, R.,Guo, J.,Li, J.,Mao, Q.,Liang, Z.
Development of In Vitro Potency Methods to Replace In Vivo Tests for Enterovirus 71 Inactivated Vaccine (Human Diploid Cell-Based/Vero Cell-Based).
Vaccines (Basel), 13:-, 2025

PubMed Abstract: The three commercial Enterovirus 71 (EV71) inactivated vaccines which have effectively controlled the EV71 pandemic currently rely on inherent variable in vivo potency methods for batch release. To align with 3R (Replacement, Reduction, Refinement) principles and enhance quality control, this study referred to WHO guidelines and the European Pharmacopoeia to develop in vitro relative potency (IVRP) methods.

PubMed: 40333322
DOI: 10.3390/vaccines13040404

Experimental method

ELECTRON MICROSCOPY (3.04 Å)