9K0G

Structure of Human HDAC2 in complex with inhibitor N-(2-aminophenyl)-4-(1-((phenylsulfonyl)methyl)-1H-1,2,3-triazol-4-yl)benzamide

This is a non-PDB format compatible entry.

Summary for 9K0G

• Entry DOI: 10.2210/pdb9k0g/pdb
• Descriptor: Histone deacetylase 2, ZINC ION, CALCIUM ION, ... (10 entities in total)
• Functional Keywords: histone deacetylase 2, transcription
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 3
• Total formula weight: 141388.90

Authors

Tojo, T.,Itoh, Y.,Kurohara, T.,Li, Y.,Singh, R.,Narozny, R.,Wiel, A.,Miyake, Y.,Yamashita, Y.,Kusakabe, K.,Uchida, S.,Suzuki, T. (deposition date: 2024-10-15, release date: 2025-10-15)

• Primary citation: Tojo, T.,Itoh, Y.,Kurohara, T.,Li, Y.,Singh, R.,Narozny, R.,Wiel, A.,Miyake, Y.,Yamashita, Y.,Kusakabe, K.,Uchida, S.,Suzuki, T.; Discovery of an HDAC2-selective inhibitor based on enzyme-inhibitor binding thermodynamics and kinetics, and its potential as a therapeutic drug for neurological disorders; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.62 Å)