9JW6

STING bound with a novel small molecule agonist

This is a non-PDB format compatible entry.

Summary for 9JW6

• Entry DOI: 10.2210/pdb9jw6/pdb
• EMDB information: 61849
• Descriptor: Stimulator of interferon genes protein, 4-[6-(2-chloranyl-6-cyclopropyl-phenyl)carbonylimidazo[1,5-a]pyrimidin-8-yl]-2-oxidanyl-benzoic acid, [(2R)-2-dodecanoyloxy-3-[oxidanyl-[(2R,3R,5S,6R)-2,3,5,6-tetrakis(oxidanyl)-4-phosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] dodecanoate (3 entities in total)
• Functional Keywords: endoplasmic reticulum, cyclic dinucleotides, signaling, adaptor protein, membrane protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 150659.87

Authors

Han, J.,Zhang, S.,Hou, Y.,Wang, Y.,Zhang, Z.,Yang, J.,Chen, K.,Liu, X.,Zhang, C. (deposition date: 2024-10-09, release date: 2025-10-15)

• Primary citation: Han, J.,Zhang, S.,Hou, Y.,Wang, Y.,Zhang, Z.,Yang, J.,Chen, K.,Liu, X.,Zhang, C.; Structural basis of STING binding with phospholipid PI4P and activation by a molecule targeting a new pocket; To Be Published,

Experimental method

ELECTRON MICROSCOPY (2.71 Å)