9JQ1

Crystal structure of EGFR T790M/C797S/L858R mutant in complex with 2,2-dichloro-N-(5-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxy-2-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)acetamide

Summary for 9JQ1

Entry DOI	10.2210/pdb9jq1/pdb
Descriptor	Epidermal growth factor receptor, 2,2-bis(chloranyl)-~{N}-[5-[[5-chloranyl-4-[(2-dimethylphosphorylphenyl)amino]pyrimidin-2-yl]amino]-4-methoxy-2-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]ethanamide (3 entities in total)
Functional Keywords	egfr, inhibitor, signaling protein
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	38215.37
Authors	Wang, Y.,Ma, L.,Yang, X. (deposition date: 2024-09-27, release date: 2025-07-02)
Primary citation	Wang, Y.,Ma, L.,Yang, X. Crystal structure of EGFR T790M/C797S/L858R mutant in complex with 2,2-dichloro-N-(5-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxy-2-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)acetamide To Be Published,
Experimental method	X-RAY DIFFRACTION (3.02 Å)

Structure validation