9JD3

membrane proteins

9JD3 の概要

• エントリーDOI: 10.2210/pdb9jd3/pdb
• EMDBエントリー: 61379
• 分子名称: Sodium- and chloride-dependent taurine transporter, DODECANE, PENTANE, ... (10 entities in total)
• 機能のキーワード: taurine, transporter, membrane protein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 72452.81

構造登録者

Yu, J.,Ge, J.P.,Zh, Y.M. (登録日: 2024-08-30, 公開日: 2025-07-16)

主引用文献

Zhang, Y.,Chen, J.,Chen, N.,Xiong, H.,Zhu, Z.,Yang, D.,Ge, J.,Yu, J.
Dimerization and substrate recognition of human taurine transporter.
Nat Commun, 16:6163-6163, 2025

PubMed Abstract: Taurine is a conditionally essential nutrient and one of the most abundant amino acids in humans, with diverse physiological functions. The cellular uptake of taurine is primarily mediated by the taurine transporter (TauT), and its dysfunction leads to retinal regeneration, cardiomyopathy, neurological and aging-associated disorders. Here we determine structures of TauT in two states: the apo inward-facing open state and the occluded state bound with substrate taurine or γ-aminobutyric acid (GABA). In addition to monomer, the structures also reveal a TauT dimer, where two cholesterol molecules act as "molecular glue", and close contacts of two TM5 from each protomer mediate the dimer interface. In combination with functional characterizations, our results elucidate the detailed mechanisms of substrate recognition, specificity and transport by TauT, providing a structural framework for understanding TauT function and exploring potential therapeutic strategies for taurine-deficiency-related disorders.

PubMed: 40615403
DOI: 10.1038/s41467-025-60967-z

実験手法

ELECTRON MICROSCOPY (3.2 Å)