9JBQ

Structure of the complex between h1F3 Fab and PcrV fragment

9JBQ の概要

• エントリーDOI: 10.2210/pdb9jbq/pdb
• 分子名称: Heavy chain, light chain, PcrV, ... (4 entities in total)
• 機能のキーワード: complex, fab, antimicrobial protein, antimicrobial protein-immune system complex, antimicrobial protein/immune system
• 由来する生物種: Homo sapiens; 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 62646.86

構造登録者

Numata, S.,Hara, T.,Izawa, M.,Okuno, Y.,Sato, Y.,Yamane, S.,Maki, H.,Sato, T.,Yamano, Y. (登録日: 2024-08-27, 公開日: 2024-09-11, 最終更新日: 2024-10-16)

• 主引用文献: Numata, S.,Hara, T.,Izawa, M.,Okuno, Y.,Sato, Y.,Yamane, S.,Maki, H.,Sato, T.,Yamano, Y.; Novel humanized anti-PcrV monoclonal antibody COT-143 protects mice from lethal Pseudomonas aeruginosa infection via inhibition of toxin translocation by the type III secretion system.; Antimicrob.Agents Chemother., 68:e0069424-e0069424, 2024; PubMed: 39269189; DOI: 10.1128/aac.00694-24

実験手法

X-RAY DIFFRACTION (2 Å)