9JB5

Crystal structure of Arabidopsis theliana FRATAXIN HOMOLOG

9JB5 の概要

• エントリーDOI: 10.2210/pdb9jb5/pdb
• 分子名称: Frataxin, mitochondrial (2 entities in total)
• 機能のキーワード: arabidopsis, metal-binding, iron transport, heme biosynthesis, transport protein
• 由来する生物種: Arabidopsis thaliana (thale cress)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 30453.83

構造登録者

Zhang, J.,Wang, J.,Liu, L. (登録日: 2024-08-26, 公開日: 2025-01-01, 最終更新日: 2025-03-19)

主引用文献

Zhang, J.,Zhou, Y.,Duan, Q.,Xu, X.,Wang, X.,Wang, J.,Liu, L.
Characterization of Arabidopsis thaliana FRATAXIN HOMOLOG in heme catabolism.
Biochimie, 231:110-115, 2025

PubMed Abstract: Frataxin plays vital roles in various iron related processes. Arabidopsis thaliana FRATAXIN HOMOLOG (AtFH) is the first identified plant frataxin and has been found to regulate the last step of heme biosynthesis. Here, we report the involvement of AtFH in heme catabolism by regulating the activity of heme oxygenase. AtFH forms a homodimer, and its crystal structure shows the dimeric interactions. A structural comparison with known frataxin structures suggests the iron binding sites, and the site for heme oxygenase activity is possibly located in a region containing Glu78. The results indicate a previously uncharacterized role of plant frataxin in heme catabolism.

PubMed: 39722354
DOI: 10.1016/j.biochi.2024.12.010

実験手法

X-RAY DIFFRACTION (2.8 Å)