9J7F

Crystal strcuture of Keap1_compound_1

This is a non-PDB format compatible entry.

Summary for 9J7F

• Entry DOI: 10.2210/pdb9j7f/pdb
• Descriptor: Kelch-like ECH-associated protein 1, ~{N},~{N}'-bis[4-[(2-azanyl-2-oxidanylidene-ethyl)-[4-[(2-azanyl-2-oxidanylidene-ethyl)-(4-methoxyphenyl)sulfonyl-amino]naphthalen-1-yl]sulfamoyl]phenyl]pentanediamide (2 entities in total)
• Functional Keywords: e3 ubiquitin ligase, ligase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 128916.01

Authors

Xu, K. (deposition date: 2024-08-18, release date: 2025-06-25)

• Primary citation: Yan, J.,Wang, T.,Yu, R.,Xu, L.,Shao, H.,Li, T.,Wang, Z.,Cha, X.,Miao, Z.,Xing, C.,Xu, K.,Liu, H.,Zhuang, C.; Chemical knockdown of Keap1 and homoPROTAC-ing allergic rhinitis; Acta Pharm Sin B, 2025; DOI: 10.1016/j.apsb.2025.05.025

Experimental method

X-RAY DIFFRACTION (2.993 Å)