9J3C

Cryo-EM structure of NAT10 with Co-enzyme A

Summary for 9J3C

• Entry DOI: 10.2210/pdb9j3c/pdb
• EMDB information: 61113
• Descriptor: RNA cytidine acetyltransferase, COENZYME A (2 entities in total)
• Functional Keywords: nat10, acyltransferase, n4-acetylcytidine, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 209246.76

Authors

Jiang, Y.,Xia, J. (deposition date: 2024-08-08, release date: 2025-04-23)

Primary citation

Xu, Z.,Zhu, M.,Geng, L.,Zhang, J.,Xia, J.,Wang, Q.,An, H.,Xia, A.,Yu, Y.,Liu, S.,Tong, J.,Zhu, W.G.,Jiang, Y.,Sun, B.
Targeting NAT10 attenuates homologous recombination via destabilizing DNA:RNA hybrids and overcomes PARP inhibitor resistance in cancers.
Drug Resist Updat., 81:101241-101241, 2025

PubMed Abstract: RNA metabolism has been extensively studied in DNA double-strand break (DSB) repair. The RNA acetyltransferase N-acetyltransferase 10 (NAT10)-mediated N4-acetylcytidine (ac4C) modification in DSB repair remains largely elusive. In this study, we aim to decipher the role for ac4C modification by NAT10 in DSB repair in hepatocellular carcinoma (HCC).

PubMed: 40132530
DOI: 10.1016/j.drup.2025.101241

Experimental method

ELECTRON MICROSCOPY (2.9 Å)