9J3C

Cryo-EM structure of NAT10 with Co-enzyme A

9J3C の概要

• エントリーDOI: 10.2210/pdb9j3c/pdb
• EMDBエントリー: 61113
• 分子名称: RNA cytidine acetyltransferase, COENZYME A (2 entities in total)
• 機能のキーワード: nat10, acyltransferase, n4-acetylcytidine, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 209246.76

構造登録者

Jiang, Y.,Xia, J. (登録日: 2024-08-08, 公開日: 2025-04-23)

主引用文献

Xu, Z.,Zhu, M.,Geng, L.,Zhang, J.,Xia, J.,Wang, Q.,An, H.,Xia, A.,Yu, Y.,Liu, S.,Tong, J.,Zhu, W.G.,Jiang, Y.,Sun, B.
Targeting NAT10 attenuates homologous recombination via destabilizing DNA:RNA hybrids and overcomes PARP inhibitor resistance in cancers.
Drug Resist Updat., 81:101241-101241, 2025

PubMed Abstract: RNA metabolism has been extensively studied in DNA double-strand break (DSB) repair. The RNA acetyltransferase N-acetyltransferase 10 (NAT10)-mediated N4-acetylcytidine (ac4C) modification in DSB repair remains largely elusive. In this study, we aim to decipher the role for ac4C modification by NAT10 in DSB repair in hepatocellular carcinoma (HCC).

PubMed: 40132530
DOI: 10.1016/j.drup.2025.101241

実験手法

ELECTRON MICROSCOPY (2.9 Å)