9J1L

Side fiber of monocin

これはPDB形式変換不可エントリーです。

9J1L の概要

• エントリーDOI: 10.2210/pdb9j1l/pdb
• 関連するPDBエントリー: 9J1J 9J1K
• EMDBエントリー: 61075
• 分子名称: Alpha-amylase, FtbP, FtbO, ... (5 entities in total)
• 機能のキーワード: bacteriocin, bacteriophage, siphoviridae, f-type tailocin, phage tail-like bacteriocins, listeria monocytogenes, monocin, cryo-em, virus like particle
• 由来する生物種: Listeria monocytogenes; 詳細
• タンパク質・核酸の鎖数: 15
• 化学式量合計: 293421.56

構造登録者

Wang, J.W.,Gu, Z.W. (登録日: 2024-08-05, 公開日: 2025-01-08, 最終更新日: 2025-03-05)

主引用文献

Gu, Z.,Ge, X.,Wang, J.
Structure of an F-type phage tail-like bacteriocin from Listeria monocytogenes.
Nat Commun, 16:1695-1695, 2025

PubMed Abstract: F-type phage tail-like bacteriocins (PTLBs) are high-molecular-weight protein complexes exhibiting bactericidal activity and share evolutionary similarities with the tails of non-contractile siphoviruses. In this study, we present the atomic structure of monocin, a genetically engineered F-type PTLB from Listeria monocytogenes. Our detailed atomic-level analysis, excluding two chaperone proteins, provides crucial insights into the molecular architecture of F-type PTLBs. The core structure of monocin resembles TP901-1-like phage tails, featuring three side fibers with receptor-binding domains that connect to the baseplate for host adhesion. Based on these findings, we propose a potential mechanism by which F-type PTLBs induce cell death, offering a foundation for developing targeted antibacterial therapies.

PubMed: 39956822
DOI: 10.1038/s41467-025-57075-3

実験手法

ELECTRON MICROSCOPY (3.28 Å)