9IPB

Local refinement structure of sEGFR and 528 Fv (from LH-type bispecific diabody Ex3) complex

Summary for 9IPB

• Entry DOI: 10.2210/pdb9ipb/pdb
• EMDB information: 60768
• Descriptor: Epidermal growth factor receptor, 528 Fv from LH-type bispecific diabody Ex3, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: bispecific antibody, diabody, egfr, lh, ex3, 528, local refinement, antitumor protein, antitumor protein-immune system complex, antitumor protein/immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 97438.91

Authors

Sato, K.,Uehara, S.,Tsugita, A.,Matsui, T.,Asano, R.,Makabe, K.,Yokoyama, T.,Tanaka, Y. (deposition date: 2024-07-10, release date: 2025-05-28)

• Primary citation: Sato, K.,Uehara, S.,Tsugita, A.,Ishii, M.,Ishiyama, S.,Maejima, A.,Nakahara, I.,Nazuka, M.,Matsui, T.,Christos, G.,Yokoyama, T.,Kumagai, I.,Makabe, K.,Asano, R.,Tanaka, Y.; Bispecific antibody-antigen complex structures reveal activity enhancement by domain rearrangement; Cell Rep, 2025

Experimental method

ELECTRON MICROSCOPY (2.93 Å)