9I2M

Crystal structure of the lipocalin cat allergen Fel d 4

Summary for 9I2M

Entry DOI	10.2210/pdb9i2m/pdb
Descriptor	Allergen Fel d 4 (2 entities in total)
Functional Keywords	lipocalin, cat allergen, ige binding, allergen
Biological source	Felis catus (domestic cat)
Total number of polymer chains	1
Total formula weight	22148.81
Authors	Todorovic, N.,Grininger, C.,Pavkov-Keller, T.,Keller, W. (deposition date: 2025-01-21, release date: 2025-12-03)
Primary citation	Todorovic, N.,Trifonova, D.,Liu, Z.,Curin, M.,Schooltink, L.,Sagmeister, T.,Grininger, C.,Kiss, R.,Gottstein, N.,Gesslbauer, B.,Winkler, A.,Pavkov-Keller, T.,Karaulov, A.,Valenta, R.,Keller, W. Major Cat Allergen Fel d 4: Structure and Identification of a Cross-Reactive IgE-Epitope-Containing Area. Allergy, 2025 Cited by PubMed Abstract: Allergic sensitization to cats and other furry animals is a major cause of asthma and allergic rhinitis in more than 200 million people worldwide. According to the frequency of IgE recognition, allergen-specific IgE levels, and allergenic activity, Fel d 4 is a major allergen in the cat (Felis domesticus). The lipocalin allergen Fel d 4 is highly homologous to dog (Can f 6) and major horse (Equ c 1) allergens. Accordingly, IgE cross-reactivity to these allergens contributes to polysensitization and allergic responses upon exposure to different animals. PubMed: 41286560 DOI: 10.1111/all.70146 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.55 Å)

Structure validation