9HJ0

Cryo-EM structure of CAK (CDK7 D97N mutant) in complex with Samuraciclib

Summary for 9HJ0

• Entry DOI: 10.2210/pdb9hj0/pdb
• EMDB information: 52207
• Descriptor: CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ... (5 entities in total)
• Functional Keywords: kinase, complex, heterotrimer, transferase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 87712.17

Authors

Cushing, V.I.,Greber, B.J.,Ali, S.,Lai, C.-F.,Bevan, C.L.,Coombes, R.C.,Buluwela, L. (deposition date: 2024-11-27, release date: 2025-08-20)

• Primary citation: Lai, C.-F.,Cushing, V.I.,Bevan, C.L.,Coombes, R.C.,Greber, B.J.,Buluwela, L.,Ali, S.; Mutation of CDK7 at a conserved residue identifies a common mechanism of acquired resistance to CDK inhibitors in cancer; To Be Published,

Experimental method

ELECTRON MICROSCOPY (2.6 Å)