9HJ0

Cryo-EM structure of CAK (CDK7 D97N mutant) in complex with Samuraciclib

9HJ0 の概要

• エントリーDOI: 10.2210/pdb9hj0/pdb
• EMDBエントリー: 52207
• 分子名称: CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ... (5 entities in total)
• 機能のキーワード: kinase, complex, heterotrimer, transferase
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 87712.17

構造登録者

Cushing, V.I.,Greber, B.J.,Ali, S.,Lai, C.-F.,Bevan, C.L.,Coombes, R.C.,Buluwela, L. (登録日: 2024-11-27, 公開日: 2025-08-20)

• 主引用文献: Lai, C.-F.,Cushing, V.I.,Bevan, C.L.,Coombes, R.C.,Greber, B.J.,Buluwela, L.,Ali, S.; Mutation of CDK7 at a conserved residue identifies a common mechanism of acquired resistance to CDK inhibitors in cancer; To Be Published,

実験手法

ELECTRON MICROSCOPY (2.6 Å)