9HD5

Crystal structure of CD73 (ecto-5'-nucleotidase) in complex with the AOPCP derivative PSB19427 in the closed state

This is a non-PDB format compatible entry.

Summary for 9HD5

• Entry DOI: 10.2210/pdb9hd5/pdb
• Descriptor: 5'-nucleotidase, ZINC ION, [[(2~{R},3~{S},4~{R},5~{R})-5-[2-chloranyl-6-[[4-[1-(2-fluoranylethyl)-1,2,3-triazol-4-yl]phenyl]methyl-propyl-amino]purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]methylphosphonic acid, ... (4 entities in total)
• Functional Keywords: ecto-5-nucleotidase, amp hydrolysis, inhibition, pet tracer, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 121397.60

Authors

Strater, N.,Moschuetz, S.,Dobelmann, C.,Schmies, C.C.,Jacobson, K.A.,Muller, C.E.,Junker, A. (deposition date: 2024-11-11, release date: 2025-11-19)

• Primary citation: Dobelmann, C.,Schmies, C.C.; Positron emission tomography (PET) tracer enables imaging of CD73 expression in cancer; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.911 Å)