9HCS

Crystal structure of human TRF1 TRFH domain in complex with compound 49

Summary for 9HCS

• Entry DOI: 10.2210/pdb9hcs/pdb
• Descriptor: Telomeric repeat-binding factor 1, N-ethyl-N'-(5-methyl-1,2-oxazol-3-yl)urea, 1,2-ETHANEDIOL, ... (5 entities in total)
• Functional Keywords: telomere, shelterin, inhibitor, protein binding
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 25865.42

Authors

Casale, G.,Le Bihan, Y.-V.,Van Montfort, R.L.M.,Guettler, S. (deposition date: 2024-11-11, release date: 2025-11-19)

• Primary citation: Casale, G.,Guettler, S.; Discovery of first-in-class inhibitors of the TRF1-TIN2 protein-protein interaction by fragment screening; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.2 Å)