9GG8

Crystal structure of 14-3-3 sigma dC - C38N in complex with Tau pS214 peptide and covalent stabilizer 187

Summary for 9GG8

• Entry DOI: 10.2210/pdb9gg8/pdb
• Descriptor: 14-3-3 protein sigma, Microtubule-associated protein tau, 4-(3,4-dihydro-2~{H}-quinoxalin-1-ylsulfonyl)benzaldehyde, ... (4 entities in total)
• Functional Keywords: 14-3-3, tau, protein-protein interaction, covalent stabilization, protein binding
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 28376.80

Authors

van den Oetelaar, M.C.M.,van de Wijngaart, T.R.,Brunsveld, L.,Ottmann, C. (deposition date: 2024-08-13, release date: 2025-08-27)

• Primary citation: van den Oetelaar, M.C.M.,Ravatt, L.,Maqueda Zelaya, F.,Oberheide, A.O.,van de Wijngaart, T.R.,van Veldhuisen, T.W.,van Boxtel, F.M.A.,Verhoef, C.J.A.,Cossar, P.J.,Wegmann, S.,Ottmann, C.,Brunsveld, L.; Modulation of Tau Condensation with 14-3-3/Tau Molecular Glues; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.1 Å)