9G7N9G7N の概要
| エントリーDOI | 10.2210/pdb9g7n/pdb |
| 分子名称 | Exotoxin A, IMIDAZOLE, ACETATE ION, ... (4 entities in total) |
| 機能のキーワード | mono-adp ribosylating toxin, exotoxin a, bacterial toxin, toxin |
| 由来する生物種 | Chromobacterium haemolyticum |
| タンパク質・核酸の鎖数 | 1 |
| 化学式量合計 | 68618.26 |
| 構造登録者 | |
| 主引用文献 | Masuyer, G.,Taverner, A.,MacKay, J.,Lima Marques, A.R.,Wang, Y.,Hunter, T.,Liu, K.,Mrsny, R.J. Discovery of mono-ADP ribosylating toxins with high structural homology to Pseudomonas exotoxin A. Commun Biol, 8:413-413, 2025 Cited by PubMed Abstract: Mono-ADP-ribosyl transferase (mART) proteins are secreted virulence factors produced by several human pathogens, the founding member being diphtheria toxin (DT). Pseudomonas aeruginosa can also secrete a mART toxin, known as exotoxin A (PE), but with an organization of its three functional domains (receptor, translocation, and enzymatic elements) that is opposite to DT. Two additional PE-like toxins (PLTs) have been identified from Vibrio cholerae and Aeromonas hydrophila, suggesting more PLT family members may exist. Database mining discovered six additional putative homologues, considerably extending this group of PLTs across a wide range of bacterial species. Here, we examine sequence and structural information for these new family members with respect to previously identified PLTs. The X-ray crystal structures of four new homologues show the conservation of critical features responsible for structure and function. This study shows the potential of these newly described toxins for the development of novel drug delivery platforms. Additionally, genomic analysis suggests horizontal gene transfer to account for the wide distribution of PLTs across a range of eubacteria species, highlighting the need to monitor emerging pathogens and their virulence factors. PubMed: 40069285DOI: 10.1038/s42003-025-07845-y 主引用文献が同じPDBエントリー |
| 実験手法 | X-RAY DIFFRACTION (1.35 Å) |
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