9G7H
Human Sirt6 in complex with ADP-ribose and the inhibitor 2-Pr
This is a non-PDB format compatible entry.
Summary for 9G7H
Entry DOI | 10.2210/pdb9g7h/pdb |
Descriptor | NAD-dependent protein deacetylase sirtuin-6, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE, ZINC ION, ... (6 entities in total) |
Functional Keywords | deacylase, inhibitor, dna-encoded chemical libraries, acyl binding pocket, aging, gene regulation |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 69726.60 |
Authors | |
Primary citation | You, W.,Montoya, A.L.,Dana, S.,Franzini, R.M.,Steegborn, C. Elucidating the Unconventional Binding Mode of a DNA-Encoded Library Hit Provides a Blueprint for Sirtuin 6 Inhibitor Development. Chemmedchem, :e202400273-e202400273, 2024 Cited by PubMed: 38940296DOI: 10.1002/cmdc.202400273 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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