9G6T

p53-Y220C Core Domain Covalently Bound to 5-Chloro-6-methylpyrazine-2-carbonitrile Soaked at 5 mM

This is a non-PDB format compatible entry.

Summary for 9G6T

• Entry DOI: 10.2210/pdb9g6t/pdb
• Related: 9G5H 9G6U
• Descriptor: Cellular tumor antigen p53, 5-chloranyl-6-methyl-pyrazine-2-carbonitrile, 1,2-ETHANEDIOL, ... (8 entities in total)
• Functional Keywords: covalent, snar, stabilization, cell cycle
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 51642.25

Authors

Stahlecker, J.,Klett, T.,Stehle, T.,Boeckler, F.M. (deposition date: 2024-07-19, release date: 2025-06-11)

• Primary citation: Klett, T.,Stahlecker, J.,Schwer, M.,Jaag, S.J.,Masberg, B.,Knappe, C.,Lammerhofer, M.,Stehle, T.,Boeckler, F.M.; SNAr Reactive Pyrazine Derivatives as p53-Y220C Cleft Binders with Diverse Binding Modes; Drug Des Devel Ther, 2025; DOI: 10.2147/DDDT.S513792

Experimental method

X-RAY DIFFRACTION (1.56 Å)