9FT6

Crystal structure of human DYRK1A in complex with ARN25697

これはPDB形式変換不可エントリーです。

9FT6 の概要

• エントリーDOI: 10.2210/pdb9ft6/pdb
• 関連するPDBエントリー: 9FR5 9FR6 9FR7 9FR8 9FR9
• 分子名称: Dual specificity tyrosine-phosphorylation-regulated kinase 1A, ~{N}4-(3-cyclobutyl-1~{H}-pyrazol-5-yl)-~{N}2-(pyridin-3-ylmethyl)furo[3,2-d]pyrimidine-2,4-diamine (2 entities in total)
• 機能のキーワード: kinase inhibitors, multitarget compounds, drug discovery, central nervous system, tauopathies, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 42378.83

構造登録者

Dalle Vedove, A.,Demuro, S.,Di Martino, R.M.C.,Balboni, B.,Tripathi, S.K.,Storici, P.,Girotto, S.,Cavalli, A. (登録日: 2024-06-24, 公開日: 2026-01-14)

• 主引用文献: Demuro, S.; Unveiling the pharmacophoric traits of balanced triple GSK-3B/FYN/DYRK1A inhibitors: rational design and synthesis of novel amino-pyrazole containing scaffolds for the treatment of Alzheimer's disease and related tauopathies.; To Be Published,

実験手法

X-RAY DIFFRACTION (3 Å)