9FS4

Crystal structure of 14-3-3 sigma in complex with Tau pS214 peptide and covalent stabilizer LD12

Summary for 9FS4

• Entry DOI: 10.2210/pdb9fs4/pdb
• Descriptor: 14-3-3 protein sigma, Microtubule-associated protein tau, 2-bromanyl-4-(2-phenylimidazol-1-yl)benzaldehyde, ... (4 entities in total)
• Functional Keywords: 14-3-3, tau, protein-protein interaction, covalent stabilization, protein binding
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 28377.60

Authors

Oetelaar, M.C.M.,Ottmann, C.,Brunsveld, L.,Engelen, S.F.H. (deposition date: 2024-06-20, release date: 2025-07-02)

• Primary citation: Oberheide, A.O.,van den Oetelaar, M.C.M.,Scheele, J.J.A.,Ottmann, C.,Cossar, P.,Brunsveld, L.,Engelen, S.F.H.; Site-selective stabilization of the 14-3-3/tau protein-protein interaction; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.6 Å)