9FS4

Crystal structure of 14-3-3 sigma in complex with Tau pS214 peptide and covalent stabilizer LD12

9FS4 の概要

• エントリーDOI: 10.2210/pdb9fs4/pdb
• 分子名称: 14-3-3 protein sigma, Microtubule-associated protein tau, 2-bromanyl-4-(2-phenylimidazol-1-yl)benzaldehyde, ... (4 entities in total)
• 機能のキーワード: 14-3-3, tau, protein-protein interaction, covalent stabilization, protein binding
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 28377.60

構造登録者

Oetelaar, M.C.M.,Ottmann, C.,Brunsveld, L.,Engelen, S.F.H. (登録日: 2024-06-20, 公開日: 2025-07-02)

• 主引用文献: Oberheide, A.O.,van den Oetelaar, M.C.M.,Scheele, J.J.A.,Ottmann, C.,Cossar, P.,Brunsveld, L.,Engelen, S.F.H.; Site-selective stabilization of the 14-3-3/tau protein-protein interaction; To Be Published,

実験手法

X-RAY DIFFRACTION (1.6 Å)