9FF8

Human transthyretin (TTR) in complex with (E)-2-((((2-chlorobenzyl)oxy)imino)methyl)benzoic acid (Lic166)

This is a non-PDB format compatible entry.

Summary for 9FF8

• Entry DOI: 10.2210/pdb9ff8/pdb
• Descriptor: Transthyretin, 1,2-ETHANEDIOL, 2-[(2-chlorophenyl)methoxyiminomethyl]benzoic acid, ... (5 entities in total)
• Functional Keywords: ttr, fibril-inhibitors, lic166-ttr crystal complex, protein transport
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 28350.38

Authors

Ciccone, L.,Shepard, W.,Sirigu, S.,Camodeca, C.,Mazzoccchi, F.,Fruchart, C.,Nencetti, S.,Orlandini, E. (deposition date: 2024-05-22, release date: 2025-06-04, Last modification date: 2025-12-17)

• Primary citation: Ciccone, L.,Camodeca, C.,Fruchart-Gaillard, C.,Thai, R.,Tonali, N.,Basta, G.,Del Turco, S.,Russo, L.,Noiray, M.,Sirigu, S.,Shepard, W.,Barlettani, L.,Mazzocchi, F.,Orlandini, E.,Nencetti, S.; New promising transthyretin stabilizers for cardiac amyloidosis treatment; Eur J Med Chem Rep, 15:100308-, 2025; DOI: 10.1016/j.ejmcr.2025.100308

Experimental method

X-RAY DIFFRACTION (1.42 Å)